Teplizumab
Written By Dr. Swati Mishra
Reviewed By Dr. Rajeev SharmaLast updated 25 Nov 2025 | 09:34 AM (UTC)
Teplizumab Uses
Teplizumab is used in the treatment of Type 1 Diabetes Mellitus.
How Teplizumab works
Teplizumab is an antibody that partially blocks the immune system’s attack on insulin-producing cells of the pancreas. In this way, Teplizumab preserves insulin production and reduces the requirement for insulin therapy.
Common side effects of Teplizumab
Lymphopenia, Rash, Decreased white blood cell count (lymphocytes), Headache
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Expert advice for Teplizumab
- Tell your healthcare provider if you have recently received or are scheduled to receive a vaccine. Teplizumab may affect the efficacy of the vaccine.
- Inform the doctor if you are currently pregnant or planning a pregnancy or if you are breastfeeding.
- Inform your doctor about an active or chronic infection or symptoms.
- Your doctor may prescribe a few anti-nausea and pain-relieving medicines for the first few days of treatment to prevent symptoms such as headache, fever, muscle and joint pain, or nausea. These side effects are not commonly observed.
Frequently asked questions for Teplizumab
You will receive this medicine once a day, continuously for 14 days.
If you miss a scheduled dose, your doctor will continue your treatment on the next scheduled day. You will not receive 2 doses on the same day.
Teplizumab is given an injection through the vein in your arm by a healthcare provider. Do not self-administer.
Teplizumab may cause serious side effects, including muscle and joint pain, fatigue, nausea, headache, fever, decreased white blood cell count, and increased liver enzymes in the blood. Inform your doctor right away if you develop such signs and symptoms.
Teplizumab injection is available as a preservative-free, sterile, clear, and colorless solution in a 1 mg/mL single-dose vial. Teplizimab has been launched in the USA by the biopharmaceutical company Provention Bio, Inc. There is no information regarding its availability in India yet.