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Regorafenib is used in the treatment of cancer of colon and rectum

How it works

In patients with cancer, a change in DNA (genetic material) triggers a signal which produces abnormal cancer cells. Regorafenib blocks this signal, and thus stops the production of these cancer cells.

Common side effects

Rash, Weakness, Reduced blood platelets, Difficulty in speaking, Haemorrhage, Vomiting, Pain, Nausea, Infection, Hair loss, Fever, Anemia, Diarrhoea, Increased blood pressure, Decreased appetite, Mucosal inflammation, Stomatitis (Inflammation of the mouth)

Available Medicine

  • ₹36730
    Bayer Pharmaceuticals Pvt Ltd
    1 variant(s)

Expert advice

  • Do not repeat dose after vomiting. Seek your doctor’s advice. In case of missed dose, take the dose as soon as you remember on the same day. Do not take a missed dose next day. 
  • Seek immediate medical attention if you experience severe chest pain which may spread from the chest to shoulders, arms, back, neck, teeth, jaw or stomach, sudden colds sweats, or fainting.
  • Inform your doctor if you have any liver disorders, bleeding disorders, high blood pressure, underwent surgery in the past or have a planned surgery.
  • Inform your doctor, if you experience vomiting, stomach pain, bowel complaints with dark stools, pain, redness or blisters on palms or soles, or non-healing wounds, severe headache, eye disturbance, fits, confusion, memory loss or any other altered mental symptoms. 
  • Do not drive or operate machinery, if you experience treatment-related symptoms which could affect your ability to concentrate and react. 
  • Men and women planning pregnancy should use effective birth control while they are taking regorafenib for 2 months after they stop taking it.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
  • Do not take if patient is allergic to regorafenib or any of its ingredients.

Frequently asked questions



Is regorafenib chemotherapy?
Yes, regorafenib is used as a chemotherapy to treat cancer of stomach (gastrointestinal stromal tumors), colon or rectal, in cases who have been treated with other cancer treatments or are incurable with other treatments


Is regorafenib FDA approved?
Yes, regorafenib has been approved by US FDA since 2012


How is regorafenib administered?
Regorafenib needs to be administered orally as advised by your doctor. It is to be taken at the same time of the day

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Does regorafenib shrink tumors?
Yes, regorafenib works either by shrinking the tumor or stops it from growing further.

Content on this page was last updated on 05 April, 2017, by Dr. Varun Gupta (MD Pharmacology)