Pegylated Liposomal Irinotecan
Written By Dr. Anuj Saini
Reviewed By Dr. Rajeev SharmaLast updated 25 Nov 2025 | 09:34 AM (UTC)
Pegylated Liposomal Irinotecan Uses
Pegylated Liposomal Irinotecan is used in the treatment of pancreatic cancer, ovarian cancer, small cell lung cancer, cervical cancer and cancer of colon and rectum.
How Pegylated Liposomal Irinotecan works
Pegylated Liposomal Irinotecan is a special form of a cancer-fighting drug called Irinotecan. Irinotecan works by blocking the ability of cancer cells to divide and grow, which eventually leads to their death. It does this by targeting an enzyme called topoisomerase I, which cancer cells need to replicate their DNA. In this formulation, Irinotecan is enclosed in tiny fat-like particles called liposomes and is pegylated, meaning it’s coated with a substance (PEG) that makes it stay in the bloodstream longer. This helps the drug stay active in the body for a longer period, giving it more time to reach the cancer cells. The liposomes also help target the drug more specifically to cancer cells, reducing the side effects on healthy cells.
Common side effects of Pegylated Liposomal Irinotecan
Diarrhea, Fatigue, Vomiting, Nausea, Decreased appetite, Stomatitis (Inflammation of the mouth), Fever, Lymphopenia, Decreased white blood cell count (neutrophils)
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Expert advice for Pegylated Liposomal Irinotecan
- Treatment with Pegylated Liposomal Irinotecan can lead to dehydration, especially if you experience diarrhea or vomiting. Drink plenty of water and electrolytes throughout the day to keep your body hydrated.
- Pegylated Liposomal Irinotecan is most effective when given on schedule. Make sure to attend all infusion appointments as directed by your doctor and inform them of any concerns or side effects between sessions.
- Pegylated Liposomal Irinotecan can affect your white blood cells, making you more prone to infections. Regular blood tests will be necessary to monitor your counts. Report any signs of infection (fever, chills) immediately.
- Fatigue is a common side effect, but light exercise like walking can help improve energy levels and mood. Rest when needed, but aim to stay active as much as you can.
- Avoid large crowds and people who are sick to reduce the risk of infection. Wash your hands frequently and practice good hygiene to keep your immune system protected.
Frequently asked questions for Pegylated Liposomal Irinotecan
Pegylated Liposomal Irinotecan is a chemotherapy drug used to treat metastatic pancreatic cancer, particularly in patients whose cancer has continued to progress after other treatments. It is used in combination with other chemotherapy drugs.
Pegylated Liposomal Irinotecan is given as an intravenous (IV) infusion, typically every two weeks, depending on your treatment plan. It is administered by a doctor or a nurse in a hospital or clinic setting.
If you experience severe diarrhea, persistent vomiting, intense abdominal pain, or symptoms of infection (such as fever), contact your doctor immediately. These could be signs of serious complications that need prompt attention.
No, ONIVYDE can harm an unborn baby, so you should avoid becoming pregnant while receiving this treatment. Additionally, you should not breastfeed while on ONIVYDE, as it could pass through breast milk and harm the baby.
There are no specific foods to avoid, but it is important to stay hydrated and eat a balanced diet. It is also important to avoid live vaccines (such as those for chickenpox or measles) and to stay away from people who are sick, as Pegylated Liposomal Irinotecan can lower your immune system.
Let your doctor know about all other medications, supplements, and treatments you are using, as some may interact with Pegylated Liposomal Irinotecan. Always consult your doctor before starting any new medication during your treatment.
Since Pegylated Liposomal Irinotecan can lower your white blood cell count, it is important to practice good hygiene, avoid close contact with sick individuals, and report any signs of infection (fever, chills, cough) to your doctor right away.
The duration of your treatment depends on how well your cancer responds to Pegylated Liposomal Irinotecan and your overall health. Your doctor will regularly monitor your progress and adjust the treatment plan as needed.