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Leuprorelin is used in the treatment of prostate cancer

How it works

Leuprorelin is a hormone similar to the one produced by the hypothalamus gland in the brain. It lowers the amount of estrogen ( a natural hormone found in females) and the amount of testosterone ( the natural hormone in males) in the body. Reducing the amount of estrogen in females is one way of treating breast cancer and endometriosis. Reducing the amount of testosterone in males may slow down or stop the spread and growth of prostate cancer cells that need testosterone to grow.

Common side effects

Decreased libido, Testicular atrophy, Increased sweating, Injection site reaction, Fatigue, Muscle weakness, Erectile dysfunction, Bone pain, Hot flashes

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Expert advice

  • Contact your doctor immediately, if you experience any allergic reactions.
  • Avoid taking leuprorelin, if you are pregnant or planning to become pregnant or breastfeeding; if you have undiagnosed abnormal vaginal bleeding.
  • Do not take leuprorelin, if you have urinary obstruction, spinal cord compression, history of pituitary gland tumors or osteoporosis.
  • Regularly monitor your blood sugar levels if you are diabetic and being treated with leuprorelin as, there may be an increase in blood sugar levels.
  • The increase in testosterone that occurs during the first weeks of therapy can cause an increase in urinary symptoms or pain.

Frequently asked questions



What is Leuprorelin used for?
Leuprorelin is used in the treatment of advanced and/or metastatic prostate cancer. It is also used to treat central precocious puberty (condition causing children to enter puberty too soon resulting in faster than normal bone growth and development of sexual characteristics), endometriosis (a condition in which the endometrium lines the uterus grows excessively and causes pain, heavy or irregular [periods], and other symptoms), anemia (lower than normal red blood cells count) due to uterine fibroids (noncancerous growth in the uterus). Leuprorelin may be used for infertility, breast cancer and before intra-uterine surgery


What is leuprorelin acetate?
Leuprorelin belongs to a class of medicines called gonadotropin-releasing hormone (GnRH) agonists


Can I take ibuprofen/ Tylenol (paracetamol)/ Benadryl (anti-cough preparation) with Lupron/leuprorelin?
There are no known drug interactions of leuprorelin with ibuprofen/ Tylenol (paracetamol)/ Benadryl.

Content on this page was last updated on 22 February, 2017, by Dr. Varun Gupta (MD Pharmacology)