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L-Valine

INFORMATION

Uses

L-Valine is used in the treatment of nutritional deficiencies.

How it works

This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of carbon atoms cannot be made by humans, these amino acids are an essential element in the diet. The catabolism of all three compounds initiates in muscle and yields NADH and FADH2 which can be utilized for ATP generation. The catabolism of all three of these amino acids uses the same enzymes in the first two steps. The first step in each case is a transamination using a single BCAA aminotransferase, with a-ketoglutarate as amine acceptor. As a result, three different a-keto acids are produced and are oxidized using a common branched-chain a-keto acid dehydrogenase, yielding the three different CoA derivatives. Subsequently the metabolic pathways diverge, producing many intermediates. The principal product from valine is propionylCoA, the glucogenic precursor of succinyl-CoA.

Common side effects

Crawling sensation on the skin, Hallucination

AVAILABLE MEDICINE

No medicine available

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)