Insulin Isophane (NPH)
How it works
Insulin isophane (nph) is an insulin. It works similar to insulin produced by the body. Insulin facilitates reuptake of glucose in muscle and fat cell and also block the release of glucose from the liver.
Common side effects
Hypoglycemia (Low blood sugar level), Injection site allergic reaction
- ₹140 to ₹390Novo Nordisk India Pvt Ltd4 variant(s)
- ₹140 to ₹1335Eli Lilly and Company India Pvt Ltd3 variant(s)
- ₹140 to ₹356Biocon3 variant(s)
- ₹140 to ₹401Lupin Ltd3 variant(s)
- ₹140 to ₹199Wockhardt Ltd2 variant(s)
- ₹144Sun Pharmaceutical Industries Ltd1 variant(s)
- ₹141Sanofi India Ltd1 variant(s)
- ₹148Shreya Life Sciences Pvt Ltd1 variant(s)
- ₹1250Novo Nordisk India Pvt Ltd1 variant(s)
- ₹152Cadila Pharmaceuticals Ltd1 variant(s)
- Do not take insulin isophane, if you experience any allergic reactions such as redness, swelling, rash and itching at the injection site, rash, itching or hives on the skin, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body.
- Take special precaution, if you are experiencing low blood sugar levels as seen by symptoms such as cold sweat; cool pale skin, headache, rapid heartbeat, feeling sick, feeling very hungry, temporary changes in vision, drowsiness, unusual tiredness and weakness; nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating.
- Inform your doctor about all the medicines you take, including vitamins and herbal supplements especially ones commonly called TZDs (thiazolidinedione) which are used as antidiabetic medicines.
- Insulin isophane preparations that are instructed to be injected under the layer of skin, do not inject it into a vein or muscle.
- Injection sites must be rotated between upper arm (deltoid), abdominal, buttocks and thigh area from one injection to the next, such that each site of prick is used not more than once in 1 to 2 weeks; this is to reduce the skin changes at injection site.
- Do not dilute or mix two preparations of insulin or insulin isophane. Also be aware that any change in strength, manufacturer, type, origin, or method of preparation may warrant a change in dose.
- Read and follow the instructions provided with the insulin isophane vial/container, for loading a cartridge, attaching a needle, performing a safety test and administering the insulin injection.
- If you experience any symptoms of hypoglycemia (such as cold sweat; cool pale skin, headache, rapid heartbeat, feeling sick, feeling very hungry, temporary changes in vision, drowsiness, unusual tiredness and weakness; nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating) you need to raise your blood sugar immediately by eating sugars or carbohydrates.
- Precaution must be taken while driving or handling machines as your ability to concentrate or react may be reduced, if you suffer from low/high blood sugar levels or you have problems with your sight.
- Do not drink alcohol while using insulin isophane.
- Avoid using insulin isophane, if you are pregnant or plan to become pregnant.
Frequently asked questions
Insulin Isophane (NPH)
Q. How does biphasic isophane insulin work?
Insulin isophane is a recombinant human insulin analogue (genetically modified insulin that is grown in a laboratory and similar to human insulin). It is an intermediate acting insulin preparation. Insulin isophane acts by replacing the normal production of insulin and by helping transfer sugar from the blood into other body tissues where it is utilized to generate energy. It also stops the liver from producing more sugar. Intermediate acting insulin preparations start acting within an hour or 2 of injection, and reach a period of peak activity that lasts up to 7 hours, following which the action trails off; overall duration of action ranges from 18 to 24 hours.