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Insulin Isophane (NPH)

Information

Uses

Insulin Isophane (NPH) is used in the treatment of type 1 diabetes and type 2 diabetes.

How it works

Insulin isophane (nph) is an insulin. It works similar to insulin produced by the body. Insulin facilitates reuptake of glucose in muscle and fat cell and also block the release of glucose from the liver.

Common side effects

Hypoglycemia (Low blood sugar level), Injection site allergic reaction

Available Medicine

  • ₹140 to ₹390
    Novo Nordisk India Pvt Ltd
    4 variant(s)
  • ₹140 to ₹1335
    Eli Lilly and Company India Pvt Ltd
    3 variant(s)
  • ₹140 to ₹356
    Biocon
    3 variant(s)
  • ₹140 to ₹401
    Lupin Ltd
    3 variant(s)
  • ₹140 to ₹199
    Wockhardt Ltd
    2 variant(s)
  • ₹144
    Sun Pharmaceutical Industries Ltd
    1 variant(s)
  • ₹141
    Sanofi India Ltd
    1 variant(s)
  • ₹148
    Shreya Life Sciences Pvt Ltd
    1 variant(s)
  • ₹1250
    Novo Nordisk India Pvt Ltd
    1 variant(s)
  • ₹152
    Cadila Pharmaceuticals Ltd
    1 variant(s)

Expert advice

  • Do not take insulin isophane, if you experience any allergic reactions such as redness, swelling, rash and itching at the injection site, rash, itching or hives on the skin, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body.
  • Take special precaution, if you are experiencing low blood sugar levels as seen by symptoms such as cold sweat; cool pale skin, headache, rapid heartbeat, feeling sick, feeling very hungry, temporary changes in vision, drowsiness, unusual tiredness and weakness; nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating.
  • Inform your doctor about all the medicines you take, including vitamins and herbal supplements especially ones commonly called TZDs (thiazolidinedione) which are used as antidiabetic medicines.
  • Insulin isophane preparations that are instructed to be injected under the layer of skin, do not inject it into a vein or muscle.
  • Injection sites must be rotated between upper arm (deltoid), abdominal, buttocks and thigh area from one injection to the next, such that each site of prick is used not more than once in 1 to 2 weeks; this is to reduce the skin changes at injection site.
  • Do not dilute or mix two preparations of insulin or insulin isophane. Also be aware that any change in strength, manufacturer, type, origin, or method of preparation may warrant a change in dose.
  • Read and follow the instructions provided with the insulin isophane vial/container, for loading a cartridge, attaching a needle, performing a safety test and administering the insulin injection.
  • If you experience any symptoms of hypoglycemia (such as cold sweat; cool pale skin, headache, rapid heartbeat, feeling sick, feeling very hungry, temporary changes in vision, drowsiness, unusual tiredness and weakness; nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating) you need to raise your blood sugar immediately by eating sugars or carbohydrates.
  • Precaution must be taken while driving or handling machines as your ability to concentrate or react may be reduced, if you suffer from low/high blood sugar levels or you have problems with your sight.
  • Do not drink alcohol while using insulin isophane.
  • Avoid using insulin isophane, if you are pregnant or plan to become pregnant.

Frequently asked questions

Insulin Isophane (NPH)

Q. How does biphasic isophane insulin work?
Insulin isophane is a recombinant human insulin analogue (genetically modified insulin that is grown in a laboratory and similar to human insulin). It is an intermediate acting insulin preparation. Insulin isophane acts by replacing the normal production of insulin and by helping transfer sugar from the blood into other body tissues where it is utilized to generate energy. It also stops the liver from producing more sugar. Intermediate acting insulin preparations start acting within an hour or 2 of injection, and reach a period of peak activity that lasts up to 7 hours, following which the action trails off; overall duration of action ranges from 18 to 24 hours.

Content on this page was last updated on 27 March, 2017, by Dr. Varun Gupta (MD Pharmacology)