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Glyceryl Trinitrate

Information

Uses

Glyceryl Trinitrate is used in the treatment of angina (chest pain) and heart failure

How it works

Glyceryl Trinitrate lowers the workload of the heart. As a result, the heart muscles do not need much blood and oxygen supply.

Common side effects

Headache, Dizziness, Flushing of face, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing)

Available Medicine

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Expert advice

  • Do not take glyceryl trinitrate tablets, if you are allergic (hypersensitive) to glyceryl trinitrate.
  • Consult your doctor, if you are pregnant, planning to become pregnant or breast feeding.
  • Do not consume alcohol while taking glyceryl trinitrate.
  • This medicine may make you drowsy or dizzy. If affected, do not drive or operate machines.

Frequently asked questions

Glyceryl Trinitrate

Q.

What is glyceryl trinitrate?
Glyceryl trinitrate belongs to a group of medicines called nitrate vasodilators.

Q.

What does glyceryl trinitrate treat?
Glyceryl trinitrate is used to prevent or stop angina pectoris (chest pain due to blockage of blood vessels of the heart) and stop spasms in the blood vessels of the heart.

Q.

Is glyceryl trinitrate a vasodilator?
Glyceryl trinitrate belongs to a group of medicines called nitrate vasodilators. It works by relaxing the blood vessels of the heart, reducing the strain on the heart and making it easier to pump blood.

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Q.

How does glyceryl trinitrate cause vasodilation?
Vasodilation with glyceryl trinitrate is achieved by the release of nitric oxide which causes the dilatation (widening) of the blood vessels by relaxing the smooth muscles of the blood vessels.

Q.

How is glyceryl trinitrate is taken?
Glycerol nitrate can be taken in the form of sublingual tablets, sprays, and transdermal patches for the treatment of angina pectoris (chest pain due to blockage of blood vessels of the heart).

Q.

Is glyceryl trinitrate a beta blocker?
Glyceryl trinitrate is not a beta blocker. Glyceryl trinitrate belongs to a group of medicines called nitrate vasodilators.

Q.

Is glyceryl trinitrate harmful?
Glyceryl trinitrate is safe if taken for prescribed duration in prescribed doses as advised by your doctor.

Q.

Is glyceryl trinitrate a steroid?
Glyceryl trinitrate is not a steroid. Glyceryl trinitrate belongs to a group of medicines called nitrate vasodilators.

Q.

What is glyceryl trinitrate spray used for?
Glyceryl trinitrate spray is used to relieve the pain of an angina attack as soon as it has started or to prevent it by using immediately before events which may cause angina, for example, exercise, emotional stress or exposure to cold.

Q.

How does glyceryl trinitrate spray work?
Glyceryl trinitrate spray is a metered aerosol which delivers a fixed amount of glyceryl trinitrate, the active ingredient, each time the button is pressed. It is to be used under your tongue and should not be inhaled. It is used to relieve the pain of an angina attack as soon as it has started or to prevent it by using immediately before events which may cause angina, for example, exercise, emotional stress or exposure to cold.

Q.

Why is glyceryl trinitrate given sublingually?
Glyceryl trinitrate is given sublingually because it is readily absorbed from the oral mucosa. Glyceryl trinitrate is also readily absorbed from the gastrointestinal tract, but due to its large breakdown (extensive first-pass metabolism) in the liver, its bioavailability (fraction of a given dose in an unchanged form that reaches the systemic circulation) is decreased.

Q.

Does glyceryl trinitrate work like sildenafil?
Both sildenafil and glyceryl trinitrate work by dilation of blood vessels which helps in a better blood flow but the mechanisms are entirely different and they are used for different conditions. Sildenafil is used for the treatment of erectile dysfunction and glyceryl trinitrate is used for the treatment of chest pain. Please consult your doctor before taking any medicine for your disease conditions.

Q.

Does glyceryl trinitrate work?
Glyceryl trinitrate works if taken in a dose for the time for which it is advised by your doctor.

Q.

Does glyceryl trinitrate cause stomach irritation?
Glyceryl trinitrate can rarely cause heartburn. Please consult your doctor if you experience excessive heartburn after taking glyceryl trinitrate.

Q.

Why does glyceryl trinitrate cause a headache?
Headache is a side effect of glyceryl trinitrate and this can be due to the dilation of cerebral arteries (those arteries supplying different parts of the brain). It usually disappears within several days of continued treatment

Q.

How does glyceryl trinitrate relieve angina pectoris?
Glyceryl Trinitrate belongs to a group of medicines called nitrate vasodilators. It acts by the release of nitric oxide which causes the dilatation (widening) of the blood vessels by relaxing its smooth muscles. This reduces the strain on the heart by making it easier to pump blood. In this manner, glyceryl trinitrate relieves pain due to angina pectoris.

Q.

How does glyceryl trinitrate reduce blood pressure?
Glyceryl trinitrate reduces the blood pressure by dilating the blood vessels and decreasing the workload of the heart. However, it is not used for the treatment of high blood pressure.


Content on this page was last updated on 08 March, 2017, by Dr. Varun Gupta (MD Pharmacology)