Dostarlimab
Written By Dr. Sakshi Jain
Reviewed By Dr. Rajeev SharmaLast updated 20 Nov 2025 | 04:56 AM (UTC)
Dostarlimab Uses
Dostarlimab is used in the treatment of Endometrial cancer.
How Dostarlimab works
Dostarlimab is an immune checkpoint inhibitor that targets immune cells' PD-1 protein (Programmed Death-1 receptor). This pathway is typically used by cancer cells to evade detection by the immune system. It inhibits PD-1 and helps immune cells identify and combat cancer cells again. This helps slow the growth of endometrial cancer and fortifies the body's defences against it.
Common side effects of Dostarlimab
Fatigue, Anemia (low number of red blood cells), Diarrhea, Nausea, Decreased white blood cell count (lymphocytes), Decreased sodium level in blood, Increased alkaline phosphatase level in blood, Low albumin level in blood
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Expert advice for Dostarlimab
- Screen patients for autoimmune disorders and transplant history before initiating therapy.
- Monitor regularly for immune-related adverse events (lungs, liver, colon, endocrine glands, skin).
- If you face any symptoms such as breathing difficulty, severe diarrhea, yellowing of skin/eyes, or unusual fatigue, report immediately.
- Avoid use in pregnancy and breastfeeding. Use contraception during and after treatment.
- Evaluating infection risks must be done by doctors before each infusion.
Frequently asked questions for Dostarlimab
It is usually given at regular intervals as prescribed by your doctor, with schedules adjusted to your condition.
Yes, it is approved as a single-agent therapy for certain types of recurrent or advanced endometrial cancer.
No, it does not cure cancer, but it helps control disease progression and prolong survival.
Regular blood tests and scans may be needed to monitor liver, thyroid, and blood counts, along with cancer response.
Always inform your doctor about other medicines, including supplements, to avoid harmful interactions.
No, it should not be used during pregnancy or breastfeeding due to potential risks to the baby.