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Crizotinib

INFORMATION

Uses

Crizotinib is used in the treatment of non-small cell lung cancer.

How it works

Crizotinib is an anti-cancer drug that belongs to a category of medicines called as protein kinase inhibitors. It acts by inhibiting the action of tyrosine kinase, an enzyme that transmits the signal for growth and spread of cancer cells.

Common side effects

Neuropathy, Decreased white blood cell count (neutrophils), Anemia, Bradycardia, Constipation, Diarrhoea, Dizziness, Bitter taste, Edema, Fainting, Fatigue, Liver toxicity, Decreased potassium level in blood, Indigestion, Loss of appetite, Nausea, Rash, Renal cyst, Vision disorder, Vomiting, Decreased white blood cell count

AVAILABLE MEDICINE

Expert advice

  • Inform your doctor before taking the medicine if you have lung problems, severe kidney disease, mild or moderate liver disease, reduced heart rate, abnormal ECG of heart, inflammation, perforation or cancer of the abdomen or intestines, or vision problems.
  • Inform your doctor before taking the medicine for treatment of any infection, mental diseases, heart problems, migraine, gout, malaria, glaucoma, or cancer.
  • You may be monitored for liver function, lung function test every month as crizotinib may cause life-threatening or fatal liver injury or inflammation of the lungs.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding. 
  • Do not drive or operate heavy machinery after taking this drug as it may cause dizziness, tiredness and problems with your vision.

Frequently asked questions

Crizotinib

Q.What is crizotinib used for?
Crizotinib is used for treating non small-cell lung cancer caused due to a mutation or defect in a gene called as anaplastic lymphoma kinase in cancer cells in patients who have not responded to previous therapies

Q.How is crizotinib administered?
Crizotinib is generally administered in the form of capsules to be taken orally

Q.How does crizotinib work?
Crizotinib works by inhibiting an enzyme called as tyrosine kinase that transmits the signal for growth and spread of cancer cells.


Content on this page was last updated on 21 November, 2016, by Dr. Varun Gupta (MD Pharmacology)