CremaGel-L Rectal Gel is a combination of two medicines used in the treatment of anal fissures (tear in the lining of the anus). It relieves the pain, swelling, itching, and discomfort associated with the passing of stool in people who suffer from problems in the anal area.
CremaGel-L Rectal Gel relaxes the blood vessels in the anus thus helping in the healing of anal fissures. It should be used in the dose and duration as directed by your doctor. Do not stop using it suddenly, as it may lead to worsening of your condition.
Before applying CremaGel-L Rectal Gel, clean and dry the affected area. Make sure to wash your hands thoroughly before and after applying this medicine. Avoid getting this medicine into your eyes, nose, or mouth. If accidental exposure occurs, wash your eyes with water and seek immediate medical attention.
CremaGel-L Rectal Gel is generally well-tolerated with minimal or no side effects. However, slight anal irritation may occur as a side effect of this medicine. This is temporary and usually resolves on its own in some time. Please consult your doctor if it does not resolve or persist for a longer duration. Inform your doctor immediately if you notice worsening of the infection or develop increased redness and irritation.
CremaGel-L Rectal Gel is used to relieve pain, irritation, or itching caused by anal fissures (tear in the lining of the anus). It relaxes the blood vessels, thereby decreasing the pressure in the anal tissues. Use it in the dose and duration advised by your doctor.
Side effects of CremaGel-L Rectal Gel
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of CremaGel-L
Limited data available
How to use CremaGel-L Rectal Gel
This medicine is for external use only. Use it in the dose and duration as advised by your doctor.
How CremaGel-L Rectal Gel works
CremaGel-L Rectal Gel is a combination of two medicines: diltiazem and lidocaine. Diltiazem relaxes the smooth muscle around the rectum and promotes blood flow to help the growth of new skin over the tear in the lining of the rectum. It reduces anal canal pressure, which diminishes pain and spasm. Lidocaine provides pain relief by numbing the skin.
Safety advice
Alcohol
No interaction found/established
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of CremaGel-L Rectal Gel during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of CremaGel-L Rectal Gel during breastfeeding is not available. Please consult your doctor.
Driving
No interaction found/established
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of CremaGel-L Rectal Gel in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of CremaGel-L Rectal Gel in patients with liver disease.
What if you forget to take CremaGel-L Rectal Gel?
If you miss a dose of CremaGel-L Rectal Gel, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Apart from using CremaGel-L Rectal Gel, you can indulge in warm baths. It may help soothe the area and thus may ease the pain.
Don't ignore the feeling of needing to pass stools. Some people suppress this feeling and put off going to the toilet until later. This may result in bigger and harder stools forming that are more difficult to pass
Do not take any oral laxative along with CremaGel-L Rectal Gel without consulting your doctor.
Sometimes certain medicines, like iron tablets or antibiotics, might make your stools hard and difficult to pass. Inform your doctor if you are taking any of them.
A fibre rich diet (wholegrain breads and cereals, fruit and green leafy vegetables), six to eight full glasses of water each day, and daily exercise are important in maintaining healthy bowel function.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
I have trouble going to the shit pot. I have pain in my anus. Please help. There is no blood in stool.
Dr. Kunal Parasar
Surgical Gastroenterology
Apply cremagel around ur anal region before going to defecate
Dear sir, When I m going to toilet (sandas) then there ( in ass) is paining & bleading after that paining is stable for 2.0 hour's. So please inform me what is the problem & suggest the solution.
Dr. Sunil Sekhri
Diabetology
it could be because of anal fissure but final diagnose requires a clinical check up
CremaGel-L Rectal Gel treats anal fissures (tears in the anal skin) by promoting healing, reducing pain, and relieving discomfort. It also helps with hemorrhoids and other related rectal or anal issues.
How do I apply CremaGel-L Rectal Gel?
Apply a pea-sized amount of CremaGel-L Rectal Gel to the affected area around the anus as prescribed, usually twice daily. Gently rub it in, and wash your hands before and after use. Do not insert the medicine inside the rectum unless advised by your doctor.
Can CremaGel-L Rectal Gel be used both inside and outside the anus?
While CremaGel-L Rectal Gel is mainly for external use, your doctor may advise gentle application just inside the anus, especially for fissures. A finger cot can be used for easier and more hygienic application.
How quickly will I feel relief after using CremaGel-L Rectal Gel?
You can expect to feel pain relief within minutes of using CremaGel-L Rectal Gel due to the numbing effect of lidocaine, a local anesthetic present in CremaGel-L Rectal Gel. The healing of the fissure may take several weeks of consistent use.
Can CremaGel-L Rectal Gel help with pain during bowel movements?
Yes, applying CremaGel-L Rectal Gel a few minutes before a bowel movement can numb the area, making it less painful to pass bowel movements, and reducing discomfort.
Can CremaGel-L Rectal Gel help me avoid surgery for anal fissures?
By promoting healing and relieving symptoms, CremaGel-L Rectal Gel can often reduce the need for surgical procedures for chronic anal fissures. However, your doctor will decide if your condition needs surgery or not based on the severity.
What else can I do to help CremaGel-L Rectal Gel work better?
Along with CremaGel-L Rectal Gel use, taking warm baths (sitz baths), eating a high-fiber diet, drinking plenty of water, and avoiding straining during bowel movements can help soothe the area and support healing.
How long should I use CremaGel-L Rectal Gel?
The CremaGel-L Rectal Gel treatment for anal fissures typically lasts for six to eight weeks to ensure the tear fully heals. Continue using it as prescribed, even if you feel better, to prevent the fissure from tearing again.
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References
Griffin N, Acheson AG, Jonas M, et al. The role of topical diltiazem in the treatment of chronic anal fissures that have failed glyceryl trinitrate therapy. Colorectal Dis. 2002 Nov;4(6):430-5. [Accessed 05 Jan. 2026]. Available from: