Diloxanide + Tinidazole + Simethicone is a combination of three medicines: Diloxanide, tinidazole and simethicone. Diloxanide is a luminal amoebicide which acts inside the intestines to kill the infection-causing microorganisms (amoeba). Diloxanide is combined with tinidazole in case of severe intestinal infections. Tinidazole is an antibiotic which kills bacteria and other infectious microorganisms by damaging the DNA. Simethicone is an antifoaming medicine which disintegrates gas bubbles and allows easy passage of gas.