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Understanding the Test
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Dr. Anupriya Nautiyal
MD Pathology, MBBS
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Very Low Density Lipoprotein

Also known as VLDL Cholesterol
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. Overnight fasting (8-12 hrs) is required. Do not eat or drink anything except water before the test.

Understanding Very Low Density Lipoprotein


What is Very Low Density Lipoprotein?

A Very Low Density Lipoprotein test is a blood test that measures the levels of very-low-density lipoprotein (VLDL) in the body. This test is used to evaluate your cardiovascular health, especially when you have risk factors, such as obesity, diabetes, and high blood pressure. It is often done as part of a routine health checkup or lipid profile.

Cholesterol is a waxy, fat-like substance found in all cells of the body and is responsible for the production of hormones and vitamin D. Very-low-density lipoprotein (VLDL) is a type of lipoprotein that is synthesized in the liver and is responsible for delivering triglycerides (a form of fat) to various tissues in the body. Once the triglycerides are delivered, VLDL cholesterol transforms into LDL (low-density lipoprotein), commonly known as the "bad" cholesterol.

A Very Low Density Lipoprotein test helps determine the levels of VLDL cholesterol in the blood when you have risk factors contributing to high VLDL levels like obesity, poorly-controlled diabetes, a sedentary lifestyle, etc. An optimal amount of VLDL cholesterol is required for the body to function properly. However, over time, elevated VLDL levels can contribute to the buildup of plaque in the arteries, increasing the risk of heart conditions, such as heart attack, stroke, and angina. Thus, maintaining healthy VLDL levels in the body is essential for overall cardiovascular health. Overnight fasting (8-12 hours) is preferred for a VLDL test. Do not eat or drink anything except water before the test. 

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them evaluate your medical condition; make recommendations for diet, exercise, or medication; and formulate an overall treatment plan.

What is Very Low Density Lipoprotein used for?

A Very Low Density Lipoprotein test is done:

  • As part of routine health checkups to measure the level of VLDL cholesterol in the blood.

  • To determine an individual's risk of developing heart disease, stroke, and peripheral artery disease.

  • To monitor the VLDL levels in individuals already diagnosed with high cholesterol or cardiovascular disease.

  • To detect early elevated levels in individuals with a family history of high cholesterol levels or premature heart disease.

What does Very Low Density Lipoprotein measure?

A Very Low Density Lipoprotein test measures the concentration of very-low-density lipoprotein (VLDL) cholesterol in the blood. VLDL cholesterol plays a vital role in the body's metabolic processes. It is produced by the liver and is used to transport triglycerides, a type of fat, from the liver to various tissues throughout the body, where they are either utilized for energy or stored for later use. Though VLDL cholesterol is essential for the body's normal functioning, it is harmful if present in excess amounts. By measuring VLDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Very Low Density Lipoprotein


Frequently Asked Questions about Very Low Density Lipoprotein

Q. What does a Very Low Density Lipoprotein test measure?

A Very Low Density Lipoprotein test measures the concentration of very-low-density lipoprotein (VLDL) cholesterol in the blood. This test helps your doctor assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies.

Q. Do I need to fast before a Very Low Density Lipoprotein test?

Yes, it is generally recommended to fast for 8-12 hours before this test. Avoid eating or drinking anything other than water during the fasting period.

Q. How can I lower my VLDL cholesterol levels?

Lifestyle modifications can help your lower VLDL cholesterol levels. These include adopting a heart-healthy diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats; engaging in regular physical activity; maintaining a healthy weight; and quitting smoking. In some cases, your doctor may also prescribe medication to help lower your VLDL cholesterol levels.

Q. What factors can affect my VLDL cholesterol levels?

Various factors can influence your VLDL cholesterol levels, including genetics, obesity, poorly-controlled diabetes, and a sedentary lifestyle. The diet also plays a significant role as consuming a diet high in saturated and trans fats can contribute to higher VLDL cholesterol levels.

Q. What are the complications associated with high VLDL cholesterol levels?

Too much VLDL cholesterol can cause the deposition of plaque in the walls of the blood vessels. Plaque is a slowly progressive disease that may result in heart diseases, such as stroke, heart attack, and peripheral artery disease.
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