Thyroid Prognostication NGS Panel near me in Kolkata

Thyroid cancer is a malignancy originating from the cells of the thyroid gland, often characterized by abnormal growths in the thyroid tissue and various subtypes with distinct clinical features and treatment approaches. The most affected pathways/genes associated with thyroid cancer progression are MAPK, PI3K, BRAF K/H, and N RAS.

This next-generation sequencing (NGS) test detects genomic biomarkers (46 genes for single nucleotide variants (SNVs) and insertions/deletions (InDels), as well as 23 genes for fusions) in thyroid nodules not only by using fluid obtained from fine-needle aspiration cytology (FNAC) before surgery but also, from formalin-fixed paraffin-embedded (FFPE) tissue blocks after surgery.

For example, this test can identify targetable mutations in genes such as BRAF, RET, and RAS, which are commonly altered in thyroid cancer. Detection of these mutations helps in selecting targeted therapies, such as BRAF inhibitors for BRAF-mutant tumors or RET inhibitors for RET-altered tumors, leading to more effective treatment and improved patient outcomes.

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