RNASE P (IC)

The RNASE P (IC) test is used in the CDC (Centers for Disease Control and Prevention) protocol as an internal control (IC) for the detection of COVID-19, since this is a multi-copy gene that is abundant in the human genome, and therefore is easily detectable. Ribonuclease P (RNase P) is an endoribonuclease that cleaves other RNA molecules at the junction between a single-stranded region and the 5′ end of a double-stranded region. The enzyme is one of only two ribozymes that can be found in all kingdoms of life (Bacteria, Archaea, and Eukarya).