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Written by
Dr. Betina Chandolia
BDS, MDS - Oral Pathology and Microbiology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Understanding Factor-VII

What is Factor-VII?

Factor-VII test or Factor-VII assay is a blood test used to measure the activity of Factor VII, also known as proconvertin. Factor VII is a protein that binds to the tissue factor and initiates the blood clotting process. Deficiency of Factor VII in the blood may lead to decreased blood clotting. The test is used to determine the abnormal clotting of blood. Factor VII deficiency can be due to use of medicines (like anticoagulants such as warfarin) and is called acquired factor VII deficiency.

While taking the blood sample, you may feel a prickling or stinging sensation or slight bruising. Consult your physician before the test if you are taking some medications like anticoagulants or blood-thinners.

Lower than normal values of Factor-VII suggest its deficiency. Normal values are 50 to 200% of reference values. A severe deficiency may result in life-threatening bleeding in the GI tract, brain, in surgeries, or from minor cuts.

What is Factor-VII used for?

  1. To measure the activity of factor VII
  2. To diagnose congenital deficiency of coagulation factor VII
  3. To monitor treatment of the Congenital deficiency of Factor VII and liver disorders
  4. For evaluating acquired deficiencies associated with liver disease, oral anticoagulant therapy, and vitamin K deficiency
  5. For investigation of a prolonged prothrombin time


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