ER/PR by IHC & Her2neu by FISH near me in Ahmedabad

Also referred as

Breast Hormone Receptor Test

Estrogen receptor (ER) Test

Progesterone receptor (PR) Test

Her2/neu Test

c-erb-B2 Test

For men & women

Earliest reports in

192 hours

Contains

1 test

Know more about this test

The ER/PR by IHC & Her2neu by FISH test checks for hormone receptors (ER and PR) and the HER2 gene in cancer tissue. It helps doctors understand how the tumor grows and decide on the best treatment, such as hormone therapy for ER/PR-positive cancers or targeted therapy for HER2-positive cases. This test supports personalized treatment planning and better outcomes in breast and other hormone-related cancers. This test is widely available with Tata 1mg labs at an affordable price in Ahmedabad.

Samples required

Tissue Block : FFPE ( Formalin-Fixed & Paraffin-Embedded)

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Preparation for this test

Sample Collection

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Understanding ER/PR by IHC & Her2neu by FISH

The ER/PR by IHC & Her2neu by FISH test is a combined diagnostic evaluation used to assess the molecular characteristics of breast and certain other cancers.

The Estrogen Receptor (ER) and Progesterone Receptor (PR) status are determined using Immunohistochemistry (IHC), a staining method that detects hormone receptor proteins on the surface of tumor cells.
The HER2/neu gene amplification is detected using Fluorescence In Situ Hybridization (FISH), a genetic test that identifies whether extra copies of the HER2 gene are present in the cancer cells.

Together, these tests help identify whether a tumor is hormone receptor-positive (likely to respond to hormone therapy) or HER2-positive (likely to respond to targeted therapy such as trastuzumab). This combined information allows doctors to plan individualized treatment strategies and predict disease behavior more accurately.

Doctors may recommend the ER/PR by IHC & Her2neu by FISH test for individuals who have been newly diagnosed with breast cancer to determine the hormone receptor status of the tumor. It is also advised for patients with recurrent or metastatic breast cancer to reassess these receptors and guide further treatment. This test helps evaluate how aggressive the cancer is, decide whether hormone therapy or targeted therapy will be effective, and monitor the response to ongoing treatment.

For this test, it is important to provide the clinical history, histopathology report, relevant test reports, and doctor’s prescription at the time of sample collection. A Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted along with the sample.

Disclaimer: In no event shall the liability of TATA 1MG exceed the amount of actual cost of test charges incurred by the customer as stated on the invoice issued by Tata 1mg.

What does ER/PR by IHC & Her2neu by FISH measure?

The ER/PR by IHC & Her2neu by FISH test detects the presence of estrogen receptor (ER), progesterone receptor (PR), and HER2/neu (c-erb-B2) proteins in breast tissue samples. These proteins help determine the hormone receptor status and aggressiveness of breast cancer. The test uses two methods: Immunohistochemistry (IHC) to assess ER and PR expression levels, and Fluorescence In Situ Hybridization (FISH) to evaluate HER2/neu gene amplification.

Understanding the expression or amplification of these markers is crucial for guiding personalized treatment. For example: hormone therapy for ER/PR-positive cancers and targeted therapy (like trastuzumab) for HER2/neu-positive cases.