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Double Marker Test- First Trimester near me in Varanasi

Also known as Dual Marker Test, Maternal Serum Screening (MSS) - First Trimester
You need to provide
Blood
This test is for
Female
Test Preparation
  1. A duly filled Maternal Serum Screen requisition form is mandatory.
  2. Provide information like maternal date of birth (dd/mm/yy), last date of the menstrual cycle (LMP), number of fetuses (single/twins), diabetic status, body weight in kg, and history of IVF, smoking, and Trisomy 21 pregnancy.
  3. Keep a hard copy of the latest pregnancy ultrasound report (Date of scan, CRL, NT in mm/NB, Level 1) - this is mandatory for combined risk assessment.
  4. The test is valid between 9 to 13 weeks of gestation (the ideal time for combined risk assessment is between 11 to 13 weeks).

Understanding Double Marker Test- First Trimester in Varanasi


What is Double Marker Test- First Trimester in Varanasi?

A Double Marker Test- First Trimester is a prenatal screening test typically conducted between the 11th and 13th week i.e., the first trimester of pregnancy, and tells about the risk of specific chromosomal abnormalities, such as Down syndrome( Trisomy 21), Edwards’s syndrome (Trisomy 18)  and Trisomy 13 in the developing fetus. This test is available at an affordable price in Varanasi with Tata 1mg labs.

This test measures the levels of two biomarkers in the mother’s blood: human chorionic gonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A). The levels of these markers, along with maternal age, gestational age, and ultrasound findings help determine the likelihood of chromosomal abnormalities in the fetus. These abnormalities can lead to various genetic conditions that can affect the baby’s growth and development. Therefore, their early detection is vital for ensuring comprehensive prenatal care and addressing potential health challenges effectively. No special preparation is required for this test. 

What does Double Marker Test- First Trimester measure?

The test is named “Double Marker” or “Dual Marker” as it primarily focuses on two biomarkers associated with chromosomal abnormalities: free beta-hCG (human chorionic gonadotropin) and PAPP-A (pregnancy-associated plasma protein-A). These, along with the USG marker and nuchal translucency (NT) measurement, are effective in Combined screening for Down syndrome and trisomy 13/18 in the fetus. This test only gives the risk for the presence of these chromosomal abnormalities in the developing fetus. A positive screen is not diagnostic but indicates that further evaluation should be considered.

hCG is synthesized by the placenta very early in pregnancy and can be detected in the blood 8-11 days after conception. Higher than normal levels of this hormone after 11 weeks of gestation indicate an increased risk for Down syndrome, while low levels indicate an increased risk for trisomy 18.

PAPP-A is a protein produced by the placenta that is needed for the implantation and maintenance of a healthy placenta (afterbirth). Low levels of PAPP-A before the 14th week of pregnancy suggest an increased risk of fetal chromosomal abnormalities.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Double Marker Test- First Trimester in Varanasi


Frequently Asked Questions about Double Marker Test- First Trimester in Varanasi

Q. What is a Double Marker Test- First Trimester, and why is it performed?

A Double Marker Test- First Trimester is a prenatal screening test that assesses the risk of chromosomal abnormalities in the developing fetus. It is performed to assess the risk of potential genetic conditions such as Down syndrome and Edwards’ syndrome.

Q. What is the difference between a Double Marker Test- First Trimester and an NT scan?

A Double Marker Test- First Trimester is a blood test, whereas an NT scan is an ultrasound. The doctor recommends both these tests during the first trimester to screen for the possible risk of chromosomal abnormalities in the unborn child.

Q. How early can a Dual Market Test be conducted during pregnancy?

A dual marker test is typically conducted during the first trimester of pregnancy, i.e., between weeks 9 and 13. But it is advised to get tested between 11 - 13 weeks along with NT values from the USG report as it gives combined risk which is better.

Q. Is a Dual Marker Test especially advised for pregnant ladies above the age of 35 years?

No, this test is also advised for younger women. It helps in screening any birth abnormalities in the fetus before birth. However, after the age of 35 years, the risk of Down syndrome increases, especially in women who have a family history of any birth defects, have given birth to a child with any birth defects previously, or have a history of insulin-dependent type 1 diabetes.

Q. What is the importance of ultrasound in a Dual Marker Test?

An ultrasound is usually advised before a Dual Marker Test. Based on the results of the ultrasound, your doctor will advise a Double Marker Test- First Trimester.

Q. What are the advantages of a Dual Marker Test?

When a Dual Marker Test is done earlier in pregnancy, it helps you to go for other diagnostic tests if the results come back positive. This will allow you and the doctor to make early decisions if needed.

Q. What if a Dual Marker Test is missed?

Suppose you miss the recommended Dual Marker Test time frame; in that case, your doctor may recommend alternative tests, such as a quad marker screening test (typically performed between the 15th and 21st week of pregnancy), depending on the stage of pregnancy.

Q. Should a Double Marker Test- First Trimester be done on an empty stomach?

This test is a non-fasting blood test. Unless the doctor instructs otherwise, you can eat or drink normally before the test.

Q. Can I book a Double Marker Test- First Trimester in Varanasi near me?

Yes, you can book a Double Marker Test- First Trimester in Varanasi near you with Tata 1mg Labs. The test can be booked easily, is affordable, and comes with an easy-to-understand report.

Q. Is home sample collection possible for a Double Marker Test- First Trimester in Varanasi?

Yes, home sample collection is possible for a Double Marker Test- First Trimester in Varanasi with Tata 1mg Labs. You can also choose a date and time that suits your schedule for sample collection.

Q. How can I book a Dual Marker Test with Tata 1mg Labs in Varanasi?

The booking process for a Dual Marker Test with Tata 1mg Labs in Varanasi is straightforward and hassle-free. Follow these steps to schedule a test online: 1). Go to the Lab Tests section on the Tata 1mg website. 2). Add your preferred test to the shopping cart. 3). Choose a time and day that works for you as long as you also take the essential prerequisites into account. 4). A confirmation notification will be sent to you with all the details once the booking is complete.

Q. What is the cost of a Double Marker Test- First Trimester in Varanasi?

Tata 1mg Labs allows you to book tests at an affordable price in Varanasi. A Double Marker Test- First Trimester can be booked at a pocket-friendly budget of Rs. 1729.

Q. How long does it take Tata 1mg Labs to provide the reports of a Double Marker Test- First Trimester in Varanasi?

We at Tata 1mg Labs recognize the value of prompt results. We strive to deliver test results with quick turnaround times so you can receive the information promptly. The reports of a Dual Marker Test in Varanasi are often provided in 80 hours.
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Double Marker Test- First Trimester test price for other cities


Price inBangaloreRs. 1729
Price inNew DelhiRs. 1829
Price inPuneRs. 1729
Price inMumbaiRs. 1829
Price inThaneRs. 1829
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References

  1. Wald N, Densem J, Stone R, Cheng R. The use of free beta-hCG in antenatal screening for Down's syndrome. Br J Obstet Gynaecol. 1993 Jun;100(6):550-7. [Accessed 22 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/7687460/ External Link
  2. Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy-associated plasma protein A as predictors of pregnancy complications. BJOG. 2000 Oct;107(10):1265-70. [Accessed 22 Sept. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/11028579/ External Link
  3. Mirsafaie M, Moghaddam-Banaem L, Kheirollahi M. The Relationship between Screening Markers in the First Trimester of Pregnancy and Chromosome Aberrations. Int J Prev Med. 2022 Apr 27;13:81. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188895/ External Link
  4. Shah KH, Anjum A, Nair P, Bhat P, Bhat RG, Bhat S. Pregnancy-associated plasma protein A: An indicator of adverse obstetric outcomes in a South India population. Turk J Obstet Gynecol. 2020 Mar;17(1):40-45. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171539/ External Link
  5. Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. 2013 Jan;28(1):3-12. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547446/#:~:text=Decreased%20levels%20of%20PAPP%2DA,increased%20risk%20of%20Down%20syndrome. External Link
  6. Commit to Healthy Choices to Help Prevent Birth Defects [Internet]. CDC; 28 June 2023 [Accessed 22 Sept. 2023]. Available from: https://www.cdc.gov/ncbddd/birthdefects/prevention.html External Link
  7. Infections in pregnancy that may affect your baby [Internet]. CDC; 10 March 2021 [Accessed 22 Sept. 2023]. Available from: https://www.nhs.uk/pregnancy/keeping-well/infections-that-may-affect-your-baby/ External Link
  8. Institute of Medicine (US) Committee on Improving Birth Outcomes; Bale JR, Stoll BJ, Lucas AO, editors. Reducing Birth Defects: Meeting the Challenge in the Developing World. Washington (DC): National Academies Press (US); 2003. 3, Interventions to Reduce the Impact of Birth Defects. [Accessed 22 Sept. 2023]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK222083/ External Link

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