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MD Pathology, MBBS
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Differential Basophil Count

You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Differential Basophil Count


What is Differential Basophil Count?

A Differential Basophil Count test measures the percentage of basophils, a type of white blood cell (WBC), in the blood. This test helps identify certain conditions such as infection, inflammation, allergy, etc. It is often done as part of a complete blood count test that also measures other types of blood cells.

Basophils play a critical part in "immune surveillance". They have the ability to detect and destroy some early cancer cells. Another important function of these cells is that they release the histamine hormone during an allergic reaction or asthma attack.

A Differential Basophil Count test helps check triggering inflammatory reactions in the body. A very high basophil count (basophilia) may signal an infection or a more serious condition, like leukemia or autoimmune disease. Whereas, a low basophil count (basopenia) could signal that your basophils are working overtime to attack an allergen or treat an infection that is taking longer than normal to heal. No special preparation is required for this test; eat or drink as per your daily routine. 

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition and formulate an overall treatment plan.

What is Differential Basophil Count used for?

A Differential Basophil Count test can be done:

  • As part of a complete blood count test to monitor your overall health.

  • To identify the cause of allergies, inflammation, or infections.

  • To detect diseases characterized by chronic inflammation.

What does Differential Basophil Count measure?

A Differential Basophil Count test measures the relative percentage of basophils in the blood. Basophils are spherically shaped small cells that originate from bone marrow and make up almost 1% of the total white blood cells in the body. These cells attack a foreign substance and release proteins, like histamine and heparin, to destroy harmful substances like allergens, pathogens, or parasites. Histamine helps widen the blood vessels and make space for more immune cells to come to the site of infection or injury, whereas heparin acts as a blood-thinning agent and helps avoid blood clotting at the infection or injury site.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Differential Basophil Count


Frequently Asked Questions about Differential Basophil Count

Q. What all conditions can a differential basophil count test detect?

A differential basophil count test can identify conditions such as infections, inflammations, allergies, or autoimmune disorders.

Q. Why is a differential basophil count test important?

A differential basophil count test is important as it helps in diagnosing and monitoring various health conditions. Basophils play a role in allergic reactions and responses to parasites, releasing chemicals that cause symptoms like itching, redness, and swelling. Normally, the number of basophils is quite low compared to other types of white blood cells. However, certain conditions can cause an increase in basophil count.

Q. How is a differential basophil count test done?

A differential basophil count test is done using a sample of blood that is withdrawn from a patient’s vein. The blood sample is collected in a vial and sent to the lab for analysis.

Q. Is there any risk associated with a differential basophil count test?

There is no risk associated with this test. However, as a needle is used to prick and collect your blood sample, you may experience bleeding, swelling, or blood collection under the skin, which is usually self-limiting. Consult your doctor if these symptoms do not recede.

Q. What does an abnormal differential basophil count mean?

An abnormal differential basophil count means that the number of basophils in the blood is outside the normal range. If your basophil count is unusually high, it is called basophilia, and if the basophil count is low, it is called basopenia.
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