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Vildagliptin

Information

Uses

Vildagliptin is used in the treatment of type 2 diabetes

How it works

Vildagliptin increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.

Common side effects

Headache, Hypoglycaemia (Low blood sugar level) in combination with insulin or sulphonylurea, Nasopharyngitis, Upper respiratory tract infection

Available Medicine

  • ₹360 to ₹721
    Novartis India Ltd
    2 variant(s)
  • ₹297 to ₹361
    USV Ltd
    2 variant(s)
  • ₹360
    Abbott India Ltd
    1 variant(s)
  • ₹360
    Emcure Pharmaceuticals Ltd
    1 variant(s)

Expert advice

  • Vildagliptin is a well tolerated and safe anti-diabetic drug and does not cause very low blood sugar levels and weight gain.
  • Take Vildagliptin with water at any time of the day with or without food. Do not chew or crush the tablets.
  • You would be at an increased risk of hypoglycemia (low blood sugar level) when insulin and sulfonylureas are also given along with, a dose adjustment may be needed. Do not change the dose yourself.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Vildagliptin can cause acute pancreatitis (swelling of your pancreas) which can be life threatening. Tell your doctor if you ever had pancreatitis, gallstones, and history of alcohol intake. 
  • If you experience severe joint pain or allergic reactions (skin rash, swelling of the face, lips, tongue and throat which causes difficulty in breathing), stop taking the medicine and inform your doctor.

Frequently asked questions

Vildagliptin

Q. What is vildagliptin?
Vildagliptin is an oral antidiabetic drug which belongs to the group of dipeptidyl peptidase 4 (DPP-4) inhibitors. It works by making the pancreas produce more insulin and less glucagon which helps to control the blood sugar level. This medicine has been shown to reduce blood sugar, which may further help to prevent complications from your diabetes.
Q. What is vildagliptin used for?
Vildagliptin belongs to a group of medicines called oral antidiabetics. Vildagliptin is used to treat adult patients with type 2 diabetes when diabetes cannot be controlled by diet and exercise alone. Vildagliptin helps to control the level of sugar in the blood either alone or together with certain other antidiabetic medicines which you will already be taking if these have not proved sufficiently effective to control diabetes.
Q. Is vildagliptin safe?
Vildagliptin is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
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Q. Does vildagliptin cause weight gain?
Body weight usually does not change with vildagliptin therapy. Weight gain has been reported when vildagliptin is used with other antidiabetic medicines like thiazolidinediones. Please consult your doctor, if you experience weight gain while taking vildagliptin.
Q. Is vildagliptin licensed with insulin?
Vildagliptin can be taken in combination with insulin when prescribed by your doctor. Always follow doctor's advice regarding its use.
Q. Does vildagliptin cause hypoglycemia?
Vildagliptin can cause hypoglycemia as an uncommon side effect when used alone. When vildagliptin is used in combination with other antidiabetic drugs, hypoglycemia is a common side effect. Please consult your doctor if you experience any symptoms of hypoglycemia while taking vildagliptin as your dose may need to be changed.
Q. Does vildagliptin cause cancer?
Vildagliptin has not been reported to cause cancer. Please consult your doctor to know more about side effects caused by vildagliptin and if you have further questions on this topic.
Q. How does vildagliptin work?
Vildagliptin belongs to the group of 'dipeptidyl peptidase 4 (DPP-4) inhibitors' which are oral antidiabetic drugs. Vildagliptin works by making the pancreas produce more insulin and less glucagon which helps to reduce the blood sugar levels.
Q. Is vildagliptin Food and Drug Administration (FDA) approved?
Vildagliptin is not Food and Drug Administration (FDA) approved. In February 2007, U.S. Food and Drug Administration (FDA) requested additional data, including a clinical study to demonstrate the safety and efficacy of vildagliptin in specific patient groups with renal impairment. While vildagliptin is currently available in many countries, it remains commercially unavailable in the United States.
Q. Is vildagliptin same as sitagliptin?
Vildagliptin and sitagliptin are two different drugs which belong to the same group of drugs known as 'dipeptidyl peptidase 4 (DPP-4) inhibitors'. Both work in a similar way to reduce the blood sugar levels.
Q. Is vildagliptin better than sitagliptin?
Vildagliptin and sitagliptin are two different drugs which belong to the same group of drugs known as 'dipeptidyl peptidase 4 (DPP-4) inhibitors'. Although vildagliptin and sitagliptin belong to the same class of medicines and have similar action with similar side effect profile, their effect may vary upon individual response. Always follow doctor's advice regarding its use.
Q. How is vildagliptin metabolized?
Vildagliptin is mainly metabolized by hydrolysis and is the major elimination pathway for vildagliptin in humans, accounting for 69% of the dose. Kidney may be one of the major organs contributing to the hydrolysis of vildagliptin to its major inactive metabolite, LAY151. Dipeptidyl peptidase 4 (DPP-4) contributes partially to the hydrolysis of vildagliptin.

Content on this page was last updated on 03 May, 2017, by Dr. Varun Gupta (MD Pharmacology)