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Trimetazidine is used to prevent heart attack.

How it works

Trimetazidine decreases the oxygen requirement of the heart by shifting its metabolism from fats to glucose. As a result, heart works more efficiently.

Common side effects

Vomiting, Nausea, Orthostatic hypotension (low blood pressure), Pale red skin, Palpitations, Itchy rash, Rash, Abdominal pain, Abnormal blood cell count, Allergic reaction, Constipation, Diarrhoea, Feeling of discomfort, Dizziness, Fall, Flushing, Headache, Inflammation of liver, Indigestion, Itching, Eye swelling, Lip swelling, Sleep disorder, Weakness


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Expert advice

  • Trimetazidine may make you feel dizzy and drowsy which may affect your ability to drive or use machinery. Trimetazidine should be discontinued if there is no treatment response after a 3 month treatment benefit assessment. Inform your doctor before you start trimetazidine:
  • If you are currently taking any other medicine
  • If you are pregnant, breastfeeding or planning to get pregnant
  • Inform your doctor immediately if you experience trembling, rigid posture, slow movements and shuffling, unbalanced walk, especially in elderly patients.
  • Caution should be exercised as falls may occur following a drop in blood pressure or loss of balance.Inform your doctor if you experience signs of angina attack (sensation of pressure, squeezing, or pain in chest) while on trimetazidine.
  • Patients with moderate kidney problems and patients above 75 years must exercise caution for increased risk to side effects while on trimetazidine.

Frequently asked questions


Q.Is trimetazidine FDA approved?
No, trimetazidine is not FDA approved

Q.What is trimetazidine/ trimetazidine dihydrochloride used for?
Trimetazidine is used in the treatment of angina pectoris (sensation of pressure, squeezing, or pain in chest due to insufficient blood supply to the muscles of the heart) as an additional therapy to other frontline medicines. It may also be used in patients who do not respond well to other anti-anginal medicines

Content on this page was last updated on 02 December, 2016, by Dr. Varun Gupta (MD Pharmacology)