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Tolbutamide is used in the treatment of type 2 diabetes

How it works

Tolbutamide increases the amount of insulin released by the pancreas in order to lower the blood glucose.

Common side effects

Fall in blood sugar level, Nausea, Headache, Dizziness

Available Medicine

  • ₹144
    Sanofi India Ltd
    1 variant(s)

Expert advice

  • Type 2 diabetes can be controlled with a proper diet alone or a diet along with exercise. A planned diet and exercising are always important when you have diabetes, even when you are taking antidiabetic medicines.
  • Low blood sugar is life-threatening. Low blood sugar may develop due to:
    • Delay or missing scheduled meals or snacks. 
    • Exercising more than usual. 
    • Drinking a significant amount of alcohol.
    • Using too much insulin. 
    • Sickness (vomiting or diarrhea).
  • Symptoms of low blood sugar (alarming signs) are fast heartbeat, sweating, cool and pale skin, feeling shaky, confusion or irritability, headache, nausea, and nightmares. Make sure that you have access to quick-acting sugar sources that treat low blood sugar. Consuming some form of quick-acting sugars immediately after the appearance of the symptoms will prevent the low blood sugar levels from worsening.
  • Consuming alcohol may increase the chance of severe low blood sugar.
  • Tolbutamide does not help patients who have type 1 diabetes.

Frequently asked questions



What is tolbutamide/ what is tolbutamide orinase/ what is tolbutamide used for?
Tolbutamide (brand name Orinase) is used in adults to control blood sugar levels in type 2 diabetes (non-insulin dependent) which cannot be controlled by diet alone


How does tolbutamide work/ how does tolbutamide lower blood glucose?
Tolbutamide helps pancreas to produce insulin which in turn helps to lower blood sugar


Is tolbutamide contraindicated for older adults?
Tolbutamide is not contraindicated for older adults, but it should used with caution and should be initiated at lower doses

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Is tolbutamide still used?
Tolbutamide is used in generic form. No brands are available for same.

Content on this page was last updated on 09 February, 2017, by Dr. Varun Gupta (MD Pharmacology)