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Tioguanine

INFORMATION

Uses

Tioguanine is used in the treatment of ovarian cancer, head and neck cancer, cervical cancer, testicular cancer., breast cancer, non-Hodgkin lymphoma (NHL), blood cancer, lung cancer, bone cancer and urinary bladder cancer.

How it works

Thioguanine nucleotides are incorporated into both the DNA and the RNA by phosphodiester linkages and inhibits tumor by inhibition of de novo purine synthesis; inhibition of purine nucleotide incorporation into the DNA and RNa blockade the utilization and synthesis of the purine nucleotides.

Common side effects

Nausea, Rash, Anemia, Dermatitis, Diarrhoea, Increased uric acid level in blood, Jaundice, Stomatitis, Loss of appetite, Reduced blood platelets, Vomiting

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Content on this page was last updated on 30 November, 2016, by Dr. Varun Gupta (MD Pharmacology)