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Sulfadoxine is used in combination with pyrimethamine for the prevention and treatment of malaria.

How it works

Sulfadoxine belong to a class of drugs called as antimalarial agents.  It works by blocking the formation of folinic acid within the malaria organism, which kills the parasite.

Common side effects

Nausea, Abdominal pain, Inflammation of nerve, Allergy, Balance disorder (loss of balance), Headache, Ringing in ear, Tingling sensation, Urticaria, Vertigo, Constipation, Diarrhoea


No medicine available

Expert advice

  • Take sulfadoxine along with food to minimize gastrointestinal side effects.
  • Take sulfadoxine with plenty of water to prevent crystalluria (crystals found in the urine when performing a urine test).
  • Avoid excessive sun exposure and wear protective clothing while taking sulfadoxine, as it may increase sensitivity to sunlight. 
  • Seek immediate medical attention if you experience signs of rash or any other allergic reaction or folate deficiency (low level of folic acid in the body).
  • You will be regularly monitored for complete blood count, liver function tests, analysis of urine for crystalluria if sulfadoxine is administered for > 3 months.
  • Do not drive or operate any machinery while taking sulfadoxine as it may cause dizziness.
  • Do not take if patient is allergic to sulfadoxine or any of its ingredients.
  • Do not take if patients with impaired kidney or liver function, blood dyscrasias (a diseased state of blood), folate deficiency, severe allergy or bronchial asthma, G6PD deficiency.
  • Do not given to Children less than 2 months.
  • Do not given to regnant women at term and breastfeeding women.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)