Information about Sitagliptin

Sitagliptin uses

Sitagliptin is used in the treatment of type 2 diabetes.

How sitagliptin works

Sitagliptin increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.

Common side effects of sitagliptin

Headache, Upper respiratory tract infection, Hypoglycaemia (Low blood sugar level) in combination with insulin or sulphonylurea, Nasopharyngitis.

Available Medicine for Sitagliptin

  • ₹238 to ₹315
    MSD Pharmaceuticals Pvt Ltd
    3 variant(s)
  • ₹239 to ₹315
    Sun Pharmaceutical Industries Ltd
    3 variant(s)

Expert advice for Sitagliptin

  • Sitagliptin is a well tolerated and safe anti-diabetic drug and does not cause very low blood sugar levels and weight gain.
  • Take Sitagliptin with water at any time of the day with or without food. Do not chew or crush the tablets.
  • You would be at an increased risk of hypoglycemia (low blood sugar level) when insulin and sulfonylureas are also given along with, a dose adjustment may be needed. Do not change the dose yourself.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Sitagliptin can cause acute pancreatitis (swelling of your pancreas) which can be life threatening. Tell your doctor if you ever had pancreatitis, gallstones, and history of alcohol intake. 
  • If you experience severe joint pain or allergic reactions (skin rash, swelling of the face, lips, tongue and throat which causes difficulty in breathing), stop taking the medicine and inform your doctor.

Frequently asked questions for Sitagliptin


Q. Is sitagliptin/ Januvia generic?
Sitagliptin is generic drug; Januvia is a brand name of sitagliptin
Q. Is sitagliptin better than vildagliptin?
Sitagliptin and vildagliptin belong to same class of drugs and are equally effective and safe in treatment of type 2 diabetes mellitus. Always consult your doctor for an alternative drug of choice that may strictly be required
Q. Is sitagliptin a statin/ insulin/ metformin?
No. Sitagliptin belongs to class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors and is a different drug than statin/insulin/metformin
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Q. Can I take Januvia with metformin/ insulin/ glipizide/ Victoza/ Lantus/ glyburide/ glimepiride/ Actos / Byetta/ Bydureon?
Sitagliptin can be taken in combination with other antidiabetic drugs, when prescribed by doctor. Always follow doctor’s advice regarding its use
Q. Does Januvia make you sleepy?
No. Januvia does not make you sleepy. Patients should follow the advice of the doctor regarding its use.
Q. Is sitagliptin/ Januvia safe?
Sitagliptin/ Januvia is safe at the prescribed dose by the doctor. Patients should follow the advice of the doctor regarding its use
Q. Is sitagliptin/ Januvia banned in India?
No. Sitagliptin is available in India
Q. Is sitagliptin FDA approved?
Yes. Sitagliptin is FDA approved
Q. Is sitagliptin/Januvia a blood thinner?
Sitagliptin/Januvia is specifically used for treatment of type 2 diabetes mellitus and not a blood thinner. Patients should follow the advice of the doctor regarding its use
Q. Does sitagliptin cause weight loss/ constipation/ joint pain/ itching/ hypoglycemia/ pancreatitis/ cancer/ dry mouth?
Sitagliptin may cause weight loss, constipation, itching, hypoglycemia, joint pain and pancreatitis. It does not cause cancer or dry mouth. However, consult your doctor if you experience any of these side effects
Q. Is Sitagliptin better than teneligliptin and alogliptin?
Sitagliptin, Teneligliptin, and alogliptin belong to the same class of drugs. They have a similar mechanism of action and efficacy to lower blood sugar levels and HbA1c. However, teneligliptin is safe to use in patients with underlying kidney disease while a dose adjustment is needed in patients with moderate to severe renal failure with Sitagliptin or alogliptin.

Content on this page was last updated on 23 June, 2017, by Dr. Varun Gupta (MD Pharmacology)