Saxagliptin is used to treat type-2 diabetes mellitus (T2DM) not controlled by diet and exercise alone and in whom metformin cannot be given due to contradiction or intolerance. If diabetes is not adequately controlled by insulin or other oral antidiabetic medicines (metformin, thiazolidinedione or sulphonylurea) or their combination, then saxagliptin can be used in a dual or triple medicine combination.
How it works
Saxagliptin is an oral antidiabetic belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It acts by inhibiting the enzyme (dipeptidyl peptidase-4 (DPP-4)) which prevents the breakdown of substances called as incretins, ultimately increasing the production of insulin that reduces blood glucose level at fasting and after intake of food.
Common side effects
Nausea, Rash, Abdominal pain, Allergic reaction, Diarrhoea, Dizziness, Fall in blood sugar level, Fatigue, Gastroenteritis, Headache, Upper respiratory tract infection, Urinary tract infection, Vomiting, Sore throat
Do not start or continue saxagliptin and consult your doctor:
- If you have allergy to saxagliptin.
- If you have type 1 diabetes or if you have serious complication of diabetes where high levels of blood acids called ketones are produced in your body (diabetic ketoacidosis).
- If you are taking insulin or other antidiabetic drug known as a sulphonylurea, your doctor may reduce the dose of your medicines, as it may otherwise cause excessively low blood glucose (hypoglycemia).
- If you have severe liver disease, kidney disease or heart failure.
- If you suffer from a disease like AIDS or have undergone organ transplant.
- If you have or have had a disease of the pancreas.
- If you are taking, have recently taken or might take any other medicines for treatment of fits, chronic pain, any infection, or high blood pressure.
Do not substitute it with insulin, if you are on insulin.
Frequently asked questions
Q. Does saxagliptin/Onglyza cause weight loss/ weight gain?
Onglyza is the trade name for saxagliptin. Saxagliptin/Onglyza does not cause weight loss/reduction. Saxagliptin/ Onglyza does not cause any apparent change in body weight.
Q. Does Kombiglyze cause weight loss (reduction)?
Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Weight loss is one of the side effect of Kombiglyze; the metformin component present in Kombiglyze may be responsible for the same. Please note, Kombiglyze is not a weight-loss drug.
Q. Does saxagliptin/Kombiglyze cause constipation?
Kombiglyze is trade name for the combination of medicines saxagliptin and metformin.. Saxagliptin/Kombiglyze does not cause constipation.
Q. Does saxagliptin/ Kombiglyze cause diarrhea?
Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/ Kombiglyze may cause diarrhea.
Q. Does saxagliptin/Kombiglyze cause hair loss?
Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/Kombiglyze does not cause hair loss.
Q. Does Onglyza have a generic?
Onglyza is the trade name of the active drug saxagliptin. Saxagliptin is not available in a generic form.
Q. Does Onglyza contain metformin?
No. It only contains saxagliptin as an active drug.
Q. Does saxagliptin/Onglyza/ Kombiglyze cause cancer?
Onglyza is a trade name for medicine saxagliptin. Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/Onglyza/ Kombiglyze has neither reported to cause any cancer, nor has any potential to cause cancer.