Information about Saxagliptin
Saxagliptin is used in the treatment of type 2 diabetes.
How saxagliptin works
Saxagliptin increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.
Common side effects of saxagliptin
Headache, Upper respiratory tract infection, Hypoglycaemia (Low blood sugar level) in combination with insulin or sulphonylurea, Nasopharyngitis
Available Medicine for Saxagliptin
- ₹546 to ₹605Dr Reddy's Laboratories Ltd2 variant(s)
- ₹1092 to ₹1210Astra Zeneca2 variant(s)
Expert advice for Saxagliptin
- If you experience stomach pain, nausea or vomiting, stop taking Saxagliptin and inform your doctor immediately.
- Saxagliptin is a well tolerated and safe anti-diabetic drug and does not cause very low blood sugar levels and weight gain.
- Take Saxagliptin with water at any time of the day with or without food. Do not chew or crush the tablets.
- You would be at an increased risk of hypoglycemia (low blood sugar level) when insulin and sulfonylureas are also given along with, a dose adjustment may be needed. Do not change the dose yourself.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
- Saxagliptin can increase the risk of acute pancreatitis (swelling of your pancreas) which can be life threatening. Tell your doctor if you have a history of pancreatitis, gallstones, or alcohol intake.
- If you experience severe joint pain or allergic reactions (skin rash, swelling of the face, lips, tongue and throat which causes difficulty in breathing), stop taking the medicine and inform your doctor.
- Tell your doctor if you are pregnant or planning to get pregnant or breastfeeding.
Frequently asked questions for Saxagliptin
Q. Does Saxagliptin cause any weight loss (reduction)?
No, Saxagliptin neither causes weight loss nor weight gain. It is weight neutral. However, weight gain can be seen when Saxagliptin is used with other antidiabetic medicines like thiazolidinediones, sulfonylureas or insulin.
Q. Can Saxagliptin cause cancer?
Saxagliptin belongs to the group of drugs called incretins which have been associated with pancreatic cancer in some clinical studies. However, a definite evidence that they cause cancer is missing, so, it is advisable to talk to your doctor regarding the same.
Q. Can I use Saxagliptin with pioglitazone?
Yes, Saxagliptin can be used with pioglitazone. A combined use of the two medicines would be more effective in controlling blood sugar levels than either medicine alone. No drug-drug interactions or any change in side effect profile has been reported compared to when they are used alone.
Q. Is Saxagliptin useful in the treatment of parkinsonism?
Saxagliptin is seen to be efficacious in the management of parkinsonism in some animal research studies only and is not advised for the management of parkinsonism in humans currently.
Q. What is the difference between Saxagliptin and vildagliptin?
Vildagliptin and Saxagliptin belong to the same class of anti-diabetic drugs. However, Vildagliptin is seen to be more effective in controlling blood sugar levels with fewer fluctuations compared to Saxagliptin. But Vildagliptin is to be taken twice a day while Saxagliptin is taken once a day.
Q. How beneficial is it to use a combination of Saxagliptin and gliclazide?
Yes, Saxagliptin and gliclazide can be taken together as they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as a dose adjustment of the two may be needed.
Q. What is the benefit of using Saxagliptin with insulin?
Saxagliptin when taken with insulin can help in lowering the insulin dose and decrease the risk of hypoglycemia (low blood sugar levels). Consult your doctor as a dose adjustment of the two may be needed.
Q. Would the results be better if I take Saxagliptin with metformin?
Yes, metformin taken along with Saxagliptin can help in better reduction of blood sugar levels compared to either drug taken alone. Moreover, fixed dose combinations of Saxagliptin with metformin are available.
Q. Are there any contraindications to the use of Saxagliptin?
Yes, the use of Saxagliptin is contraindicated in some conditions like a history of allergy to Saxagliptin, any ingredients of this drug or to any other drug of the same class. Saxagliptin should also be avoided in patients with a history of pancreatitis.
Q. Can I use Saxagliptin with dapagliflozin?
Yes, Saxagliptin can be used along with dapagliflozin. Both are antidiabetic drugs and can achieve better reduction of blood sugar levels when used together and can lower the risk of hypoglycemia and help in better reduction of body weight.
Q. Is the use of Saxagliptin is associated with a high risk of heart failure?
Yes, there are some cases of Saxagliptin-induced heart failure reported especially in patients with additional risk factors for heart failure. In case the patient develops symptoms of heart failure like increasing shortness of breath, the rapid increase in weight and swelling of the feet (pedal edema). Stop taking Saxagliptin and inform your doctor.
Q. How effective is Saxagliptin for diabetes mellitus?
Saxagliptin is indicated along with dietary modification and exercise in adults with type 2 diabetes mellitus. It is seen to significantly reduce blood glucose levels and glycosylated hemoglobin (HbA1c) when taken as a single drug or in combination with other anti-diabetic drugs.
Q. What is the difference between Saxagliptin and alogliptin?
Both, Saxagliptin and alogliptin are antidiabetic drugs of same class. They are similar in terms of efficacy and safety. The only difference is that Alogliptin is longer acting than Saxagliptin, still, both are given once a day.
Q. What is the difference between Saxagliptin and glimepiride?
Both Glimepiride and Saxagliptin are antidiabetic drugs but they belong to different classes and have different side effect profiles. Glimepiride commonly causes hypoglycemia and weight gain while Saxagliptin causes a headache and nasopharyngitis.
Q. Is Saxagliptin better than sitagliptin?
Saxagliptin and Sitagliptin and belong to the same class of drugs and are equally effective and safe in the treatment of type 2 diabetes mellitus. For severely compromised renal patients dosage adjustment is required for both drugs but with mild to moderate renal impairment no dosage adjustment is required with sitagliptin.
Q. Is Saxagliptin better than linagliptin?
Both Saxagliptin and linagliptin belong to the same class of drugs with a similar mechanism of action and efficacy to lower blood sugar levels and HbA1c. However, linagliptin is safe to use in patients with underlying kidney disease while a dose adjustment is needed in patients with moderate to severe renal failure with Saxagliptin.
Q. Is it beneficial to use Saxagliptin with glipizide?
Yes, it is beneficial to take Saxagliptin and glipizide. Both are antidiabetic drugs, however, they work in different ways. When taken together, they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase if the dose of glipizide is not adjusted.