Probenecid

Information about Probenecid

Probenecid Uses

Probenecid is used in the treatment of gout.

How Probenecid works

Probenecid is a urine alkalizer. It works by increasing the pH of urine which makes it less acidic. This helps the kidneys get rid of excess uric acid, thereby preventing gout and certain types of kidney stones.

Common side effects of Probenecid

Nausea, Vomiting, Headache, Gout flares, Fever, Rash, Aplastic anemia, Hemolytic anemia, Decreased white blood cell count (lymphocytes)
CONTENT DETAILS
Written By
Dr. Radhika Dua
MDS, BDS
Reviewed By
Dr. Shilpa Garcha
MD (Pharmacology), MBBS
Last updated
18 Feb 2020 | 11:51 AM (UTC)

We provide you with authentic, trustworthy and revelant information

Want to know more

Available Medicine for Probenecid

Expert advice for Probenecid

  • Do not use probenecid along with salicylates like aspirin.
  • You may be prescribed colchicine or non-steroidal anti-inflammatory agent (NSAID, pain killer) to prevent severe gouty attacks during the first 6 to 12 months of probenecid therapy.
  • Consult your doctor before starting probenecid treatment if you have or ever had kidney stones, any other kidney disorder, ulcers in the stomach and small intestine (peptic ulcers),diabetes, severe liver disorders, blood disorders or glucose 6-phosphate dehydrogenase (G6PD) deficiency.
  • Inform your doctor about any scheduled surgery for which you would be receiving anesthetics.
  • You should take adequate water or fluids while taking probenecid to prevent kidney stones.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • Take precautions while driving or operating machinery, as probenecid is known to cause dizziness.

Frequently asked questions for Probenecid

Probenecid

Q. Is probenecid an NSAID/ antibiotic/ sulfa drug/ diuretic?

No. Probenecid belongs to a class of medications called uricosuric agents and is used to reduce high levels of uric acid in the body and to prevent and treat gout and gouty arthritis. It has no anti-inflammatory effect like NSAIDs or activity against infections like antibiotics or sulfa drugs. It is only used in combination with antibiotics (e.g. penicillin, ampicillin, amoxicillin etc.) to prolong their effect during infection. It has no effect on increasing urine output and is not a diuretic

Q. Probenecid is combined with penicillin/ why is probenecid given with penicillin/ how does probenecid work with penicillin/ how does probenecid increase penicillin/ what effect does probenecid have on penicillin?

In certain cases of serious infections (e.g. gonorrhea or neurosyphillis) probenecid may be prescribed along with antibiotics like penicillin to prolong the effect of the antibiotics given by any route. Probenecid inhibits the elimination (excretion from blood into the urine) of certain antibiotics like penicillin by the kidneys thereby delaying its excretion and increasing concentration in the blood

Q. What is Probenecid used for?

Probenecid is a uricosuric agent and is used to reduce high levels of uric acid in the body and to prevent and treat gout and gouty arthritis (pain and inflammation of small joints due to deposition of uric acid in the joint). It is also used to prolong the effect of antibiotics (e.g. penicillin)

Q. Does Probenecid cause kidney stones?

Yes. Kidney stones are among the known side effects of Probenecid treatment.

INDIA’S LARGEST HEALTHCARE PLATFORM

260m+
Visitors
31m+
Orders Delivered
1800+
Cities
Get the link to download App

Connect

  • Social Links
  • Want daily dose of health?
Download App
Reliable

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform

Know more about Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.

© 2022 Tata 1mg. All rights reserved. In compliance with Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945, we don't process requests for Schedule X and other habit forming drugs.