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Mirtazapine is used in the treatment of depression

How it works

Mirtazapine works in depression by increasing the levels of chemical messengers in the brain that helps in regulating mood.

Common side effects

Nausea, Nightmare, Nocturia (increased urge to urinate during the night), Excessive thirst, Abdominal pain, Agitation, Anxiety, Back pain, Carelessness, Chills, Confusion, Constipation, Convulsion, Decreased blood pressure, Decreased sexual function, Depersonalisation (feelings of being outside the body), Dizziness, Fainting on standing, Dizziness on standing, Drowsiness, Dry mouth, Pain during periods, Shortness of breath, Excitement, Fever, Increased sensitivity to touch, Increased appetite, Mood changes, Mood swings, Mouth ulcer, Muscle pain, Rash, Sore throat, Swelling, Thought abnormality, Tremor, Trembling, Vertigo, Auditory hallucination, Visual hallucination, Vomiting, Weight loss, Weight gain

Available Medicine

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Expert advice

  • Do not start or continue the mirtazapine tablets if you are allergic (hypersensitive) to mirtazapine or any of the other ingredients of mirtazapine medication; If you are taking or have taken monoamine-oxidase (MAO) inhibitor within last 14 days.
  • Avoid taking mirtazapine, if you are pregnant or breastfeeding.
  • Doctor’s advice should be considered in case of following disease conditions: liver or kidney disease, increased pressure inside the eye that causes visual problems (narrow-angle glaucoma), bipolar disorder (manic depression), fits (seizures or epilepsy), low blood pressure (hypotension), dizzy spells, high cholesterol or triglycerides, heart disease, chest pain (angina), a history of heart attack or stroke, or a history of drug abuse or suicidal thoughts.

Frequently asked questions


Q. Is mirtazapine an SSRI/ MAOI/opiate/ narcotic/ benzo/tricyclic antidepressant?
Mirtazapine is a tetracyclic antidepressant. It is not SSRI/ MAOI/opiate/narcotic

Q. Is mirtazapine addictive?
No, mirtazapine is not addictive. Patient should follow the advice of the doctor regarding its use

Q. Is mirtazapine safe?
Mirtazapine is safe if used at prescribed dose and duration as advised by your doctor

Q. Can I take mirtazapine forever?
No, patient should take mirtazapine for the given duration as advised by your doctor

Q. Can I take mirtazapine for sleep with citalopram?
No, Patient should not take mirtazapine with citalopram because it may cause serious side effects. Always consult your doctor regarding its use

Q. Can you take mirtazapine for sleep?
Mirtazapine is specifically used to treat major depressive disorder. Patient should follow the advice of the doctor regarding its use

Q. Can I take mirtazapine with sertraline/ citalopram/ fluoxetine/ antibiotics/ zopiclone/ amitryptline/ tramadol/ diazepam/ ambien/ Xanax?
Taking other medicines may alter the effects of mirtazapine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required

Q. Does mirtazapine cause weight gain/memory loss/ insomnia/ make you eat more/ make you constipated?
Mirtazapine may cause these side effects. However, consult your doctor if you experience any of these symptoms

Q. Does mirtazapine treat anxiety/lower seizure threshold?
Mirtazapine may be used to treat anxiety but not to lower the seizure threshold. Care should be taken in patients with seizures

Q. Does mirtazapine contain benzodiazepine?
No, it does not contain benzodiazepine.

Content on this page was last updated on 28 December, 2016, by Dr. Varun Gupta (MD Pharmacology)