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Mirabegron + Silodosin

Written By Dr. Lipika KhuranaReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:37 AM (UTC)

Mirabegron + Silodosin Uses

Mirabegron+Silodosin is used in the treatment of benign prostatic hyperplasia.

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How Mirabegron + Silodosin works

Mirabegron + Silodosin is a combination of mirabegron and silodosin. Mirabegron relaxes the bladder muscles to prevent urgent, frequent, or uncontrolled urination. Silodosin relaxes the muscles of the bladder and prostate.

Common side effects of Mirabegron + Silodosin

Retrograde ejaculation, Dizziness, Diarrhea, Orthostatic hypotension (sudden lowering of blood pressure on standing), Headache, Nasopharyngitis (inflammation of the throat and nasal passages), Nasal congestion (stuffy nose)
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Expert advice for Mirabegron + Silodosin

  • Mirabegron + Silodosin may raise your blood pressure. Monitor your blood pressure regularly.
  • Avoid drinking too much water before going to bed as it will increase your urge to go to the toilet and thus disturb your sleep.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and review your treatment.

Frequently asked questions for Mirabegron + Silodosin

Yes, this medicine may cause a drop in the blood pressure. This most commonly occurs while taking the first dose of this medicine. Hence, you should be cautious while driving, operating any machinery, or doing any important work during the initial days of the treatment. Consult your doctor before you start taking this medication.
You must consult your doctor before you start taking these medications. Mirabegron+Silodosin can sometimes cause low blood pressure and fainting. Taking sildenafil along with Mirabegron+Silodosin can further deteriorate the condition. It could also lead to increased chances of a drop in blood pressure in a few sensitive patients. As a result, there could be an increase in the chances of fainting which could be dangerous.
No, do not stop taking Mirabegron+Silodosin even if you start feeling better. This medicine does not cure prostatic hyperplasia but relieves the symptoms like painful, frequent urination and reduces the urgency to urinate. Stopping the treatment may result in the recurrence of prostatic hyperplasia symptoms.