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Pharmaceutical Aid

How it works

Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.

Common side effects

Vomiting, Nausea, Nystagmus (involuntary eye movement), Abdominal pain, Coma, Apnea (absence of breathing), Altered heart rate, Vertigo, Balance disorder (loss of balance), Contact dermatitis, Drowsiness


No medicine available

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)