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Vitamin K deficiency, severe hypoprothrombinaemia.

How it works

Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin).

Common side effects

Inflammation of a vein, Shock, Cardiovascular collapse, Chest tightness, Chest pain, Cyanosis (bluish discoloration of the skin), Shortness of breath, Flushing, Increased sweating, Injection site reaction


Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)