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Lumefantrine is used in combination with artemether in the treatment of malaria caused by Plasmodium falciparum.

How it works

Lumefantrine is an antimalarial drug which accumulates within the malaria parasite and inhibits the breakdown of hemoglobin. It forms a toxic complex with heme (part of hemoglobin) in the parasite, and also damages the parasite cell membrane, thereby killing it.

Common side effects

Nausea, Skin rash, Allergic reaction, Altered heart rate, Difficulty in speaking, Chills, Dizziness, Difficulty in swalloing, Shortness of breath, Facial swelling, Lip swelling, Fainting, Fever, Headache, Insomnia, Loss of appetite, Muscle pain, Joint pain, Sore tongue, Vomiting, Weakness, Fatigue


No medicine available

Expert advice

  • Lumefantrine should be taken with food.
  • Inform your doctor if you have Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), severe liver or kidney problems, heart disorder, especially as an abnormal electrical tracing (ECG showing prolonged QTc interval).
  • Caution is advised if you were previously infected with both the “Plasmodium falciparum” and “Plasmodium vivax” parasites.
  • Other medicines for the treatment of malaria, especially quinine, halofantrine, mefloquine are not advised to be taken along with lumefantrine.
  • Inform your doctor if you feel your malaria is getting worse, or you feel too unwell or are unable to eat.
  • Women may not breast feed after taking lumefantrine. Breast feeding may be resumed after at least one week post taking this medicine.
  • Do not drive or use heavy machinery, if artemether+lumefantrine make you feel sleepy, dizzy or generally weak.

Frequently asked questions


Q. Is lumefantrine an antibiotic?
Lumefantrine is an antimalarial antibiotic.
Q. How does lumefantrine work?
Lumefantrine works by killing the organism (plasmodium) that causes malaria. The exact mechanism of action of the drug is unknown.
Q. What does lumefantrine treat?
Lumefantrine is used in combination with artemether for treatment of malaria.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)