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    Linagliptin

    Information about Linagliptin

    Linagliptin uses

    Linagliptin is used in the treatment of type 2 diabetes.

    How linagliptin works

    Linagliptin increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.

    Common side effects of linagliptin

    Hypoglycaemia (Low blood sugar level) in combination with insulin or sulphonylurea, Headache, Nasopharyngitis

    Available Medicine for Linagliptin

    • ₹450
      Boehringer Ingelheim
      1 variant(s)
    • ₹468
      Lupin Ltd
      1 variant(s)

    Expert advice for Linagliptin

    • If you experience stomach pain, nausea or vomiting, stop taking Linagliptin and inform your doctor immediately.
    • Linagliptin is a well tolerated and safe anti-diabetic drug and does not cause very low blood sugar levels and weight gain.
    • Take Linagliptin with water at any time of the day with or without food. Do not chew or crush the tablets.
    • You would be at an increased risk of hypoglycemia (low blood sugar level) when insulin and sulfonylureas are also given along with, a dose adjustment may be needed. Do not change the dose yourself.
    • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
    • Linagliptin can increase the risk of acute pancreatitis (swelling of your pancreas) which can be life threatening. Tell your doctor if you have a history of pancreatitis, gallstones, or alcohol intake.
    • If you experience severe joint pain or allergic reactions (skin rash, swelling of the face, lips, tongue and throat which causes difficulty in breathing), stop taking the medicine and inform your doctor.
    • Tell your doctor if you are pregnant or planning to get pregnant or breastfeeding.

    Frequently asked questions for Linagliptin

    Linagliptin

    Q. Is Linagliptin safe?
    Linagliptin is safe when used at prescribed doses for the prescribed duration as advised by your doctor. However, some common side effects that you can experience at the dose advised, includes headache, hypoglycemia (low blood sugar level) when used with insulin or sulphonylurea, upper respiratory tract infection and nasopharyngitis.
    Q. Is Linagliptin available in India?
    Yes, Linagliptin is available in India as a prescription medicine.
    Q. What is Linagliptin?
    Linagliptin is an oral antidiabetic drug which belongs to the group of dipeptidyl peptidase 4 (DPP-4) inhibitors. It lowers the blood sugar levels by increasing the release of insulin and decreasing glucagon levels. It has a lesser risk of hypoglycemia compared to other drugs and does not cause weight gain.
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    Q. Can I take Linagliptin with insulin detemir?
    Yes, you can take Linagliptin with insulin detemir, a long-acting insulin analog which maintains the basal insulin levels. Using them together can lower the insulin dose and decrease the risk of hypoglycemia (low blood sugar levels).
    Q. Would it be much better if I take Linagliptin with insulin?
    Yes, using Linagliptin with insulin can help in better control of your blood sugar levels than insulin alone. Using them together can help to lower the insulin dose and decrease the risk of hypoglycemia (low blood sugar levels).
    Q. What if I take Linagliptin with alogliptin?
    No, Linagliptin preferably should not be taken with alogliptin. As both the medicines belong to the same class of drugs and a combination of these can cause an increase in the risk of side effects especially pancreatitis.
    Q. How different is Linagliptin from vildagliptin?
    Both Linagliptin and Vildagliptin belong to the same class of drugs. Vildagliptin is seen to be more effective in controlling the blood sugar levels, however, it is to be taken twice a day and is eliminated from kidneys while Linagliptin is once a day medicine and is eliminated from liver. So, Linagliptin is safe to use in kidney disease patients without any dose adjustment.
    Q. What is the best time to take Linagliptin?
    Linagliptin is to be taken once a day and at around the same time every day. There is no interaction with food so Linagliptin can be taken with or without food.
    Q. Is Linagliptin safe to use in patients with an underlying cardiac disease?
    Yes, Linagliptin is safe to use in patients with an underlying cardiac disease like heart failure, angina (pain due to decreased blood supply to the heart), myocardial infarction (death of the heart tissue) and even stroke (blockage of blood vessels supplying the brain).
    Q. Can I take Linagliptin with metformin?
    Yes, Linagliptin can be taken with metformin. It is a good add-on treatment if the blood sugars are very high even after taking metformin in maximum tolerated dose. Together they would help in better control of blood sugar levels. However, consult your doctor before taking them together as a dose adjustment may be needed.
    Q. How is Linagliptin similar to teneligliptin?
    Both Linagliptin and teneligliptin belong to the same class of drugs with a similar mechanism of action and efficacy to lower blood sugar levels and HbA1c. Both have a similar side effect profile and both are safe in patients with underlying kidney disease.
    Q. How is Linagliptin better than sitagliptin?
    Linagliptin and sitagliptin belong to the same class of drugs with a similar mechanism of action and efficacy to lower blood sugar levels and HbA1c. However, Linagliptin is safe to use in patients with underlying kidney disease while a dose adjustment is needed in patients with moderate to severe renal failure with sitagliptin.
    Q. Does Linagliptin cause weight loss?
    No, Linagliptin does not cause weight loss. It does not cause any weight gain as well.
    Q. How safe is Linagliptin compared to other gliptins?
    All the gliptins have a similar mechanism of action and a similar efficacy to lower blood sugar levels and HbA1c. However, Linagliptin and teneligliptin are safe to use in patients with underlying kidney disease while a dose adjustment of other gliptins is needed in patients with moderate to severe renal failure.
    Q. When should I stop taking Linagliptin?
    Stop taking Linagliptin if you develop an allergic reaction like rash or breathlessness and if you have a persistent and severe stomach ache as it could be a sign of pancreatitis. Immediately contact your doctor or the emergency of a hospital.
    Q. What are the special precautions to take care of while taking Linagliptin?
    Use of Linagliptin with insulin or sulfonylureas can increase the risk of hypoglycemia (low blood sugar), which may need a dose adjustment. Be aware of the symptoms and always carry something sweet with you. Stop taking Linagliptin if you develop an allergic reaction like rash or breathlessness and if you have a persistent and severe stomach ache as it could be a sign of pancreatitis.
    Q. Is it safe to use Linagliptin with pioglitazone?
    Yes, it is safe to use Linagliptin with pioglitazone. No drug-drug interactions have been reported and the side effect profile is similar to the drugs used alone.
    Q. Is Linagliptin better than saxagliptin ?
    Both Linagliptin and saxagliptin belong to the same class of drugs with a similar mechanism of action and efficacy to lower blood sugar levels and HbA1c. However, Linagliptin is safe to use in patients with underlying kidney disease while a dose adjustment is needed in patients with moderate to severe renal failure with saxagliptin.

    Content on this page was last updated on 13 August, 2017, by Dr. Varun Gupta (MD Pharmacology)