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Lifitegrast

Written By Dr. Sakshi JainReviewed By Dr. Rajeev Sharma
Last updated 01 Aug 2025 | 07:39 AM (UTC)

Lifitegrast Uses

Lifitegrast is used in the treatment of dry eyes.

How Lifitegrast works

Lifitegrast interferes by inhibiting a protein known as LFA-1 (lymphocyte function-associated antigen-1) from attaching to another protein called ICAM-1 (intercellular adhesion molecule-1) on the surface of the eye. This is an important step in the inflammatory response that leads to the symptoms of dry eye. By inhibiting this attachment, Lifitegrast decreases inflammation and allows a more balanced tear film to be restored, thereby easing irritation and discomfort.

Common side effects of Lifitegrast

Eye irritation, Metallic taste, Reduced visual acuity
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Expert advice for Lifitegrast

  • Apply the Lifitegrast as instructed, ensuring even coverage while avoiding overuse to prevent potential side effects.
  • Always wash your hands before and after applying the medication.
  • Store Lifitegrast as directed, usually in a cool, dry place, and keep it out of reach of children.

Frequently asked questions for Lifitegrast

It helps with redness caused by dryness, but may not treat other causes of redness.
Yes, it can be used before bed to keep the eyes hydrated overnight.
Some people may experience temporary blurred vision, but it clears up quickly.
No, it is not habit-forming and can be used as needed.
If you have known allergies to its ingredients, avoid use and consult your doctor.
Yes, it can soothe irritation caused by environmental factors.