Ivosidenib
Written By Dr. Sakshi Jain
Reviewed By Dr. Rajeev SharmaLast updated 31 Jul 2026 | 05:57 PM (UTC)
Ivosidenib Uses
Ivosidenib is used in the treatment of Acute Myeloid Leukemia, myelodysplastic syndrome and Cholangiocarcinoma.
How Ivosidenib works
Ivosidenib works by blocking an abnormal protein called isocitrate dehydrogenase-1 (IDH1) that helps certain cancer cells grow. By blocking this protein, Ivosidenib slows the growth of cancer cells and supports the development of healthier cells. This helps slow disease progression.
Common side effects of Ivosidenib
Tiredness, Diarrhea, Nausea, Joint pain, Muscle pain, Rash, Cough, Breathlessness, Abdominal pain, Sores
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Expert advice for Ivosidenib
- Take Ivosidenib at about the same time each day to help maintain consistent medicine levels in your body.
- Ivosidenib may be taken with or without food, but avoid high-fat meals, as they can increase the amount of medicine absorbed.
- Keep all scheduled ECG appointments and blood tests so your doctor can monitor your heart rhythm and overall health during treatment.
- Seek medical attention immediately if you develop symptoms of differentiation syndrome, such as fever, difficulty breathing, rapid weight gain, or swelling, as early treatment is essential.
- Report symptoms such as dizziness, fainting, irregular heartbeat, muscle weakness, numbness, or tingling to your doctor promptly, as these may indicate serious side effects that require medical attention.
- Use effective contraception during treatment and for the recommended period after your last dose if you or your partner can become pregnant. Discuss suitable contraceptive methods with your doctor before starting treatment.
Frequently asked questions for Ivosidenib
Ivosidenib can affect your heart rhythm and may also cause changes in your blood counts and electrolyte levels. Regular electrocardiograms (ECGs) and blood tests help your doctor monitor these changes and manage them early if needed.
Differentiation syndrome is a serious complication that can occur in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) receiving Ivosidenib. Contact your doctor immediately if you develop fever, difficulty breathing, rapid weight gain, swelling, low blood pressure, or reduced urination, as early treatment is important.
For people with AML or MDS, treatment is generally continued for at least 6 months, provided it is tolerated and the disease has not worsened. This allows enough time for the medicine to produce a clinical response.
Always tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, herbal products, and dietary supplements you are taking.
Contact your doctor immediately if you experience dizziness, fainting, palpitations, or an irregular heartbeat. These may be signs of changes in your heart rhythm that require prompt medical evaluation.
Although uncommon, Ivosidenib may rarely cause Guillain-Barré syndrome, a serious nerve disorder. Seek medical attention immediately if you develop muscle weakness, numbness, tingling, or difficulty breathing.