Insulin Aspart Protamine
Treatment of Diabetes mellitus in adults, adolescents and children aged 10 years and above.
How it works
Insulin aspart protamine binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC),
Common side effects
Peripheral neuropathy, Diabetic retinopathy, Fall in blood sugar level, Lipodystrophy