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    Information about Glipizide

    Glipizide uses

    Glipizide is used in the treatment of type 2 diabetes mellitus. It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

    How glipizide works

    Glipizide is an anti-diabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose.

    Common side effects of glipizide

    Hypoglycemia (low blood sugar level), Nausea, Headache, Dizziness
    Content Details
    Written By
    Dr. Anuj Saini
    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    17 May 2019 | 07:27 PM (IST)
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    Read Our Editorial Policy

    Available Medicine for Glipizide

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    Expert advice for Glipizide

    • Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
    • Be careful while driving or operating machinery until you know how Glipizide affects you.
    • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
    • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
    • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

    Frequently asked questions for Glipizide


    Q. Can you take glipizide with sulfa allergy?

    You can take glipizide if you are not allergic to glipizide or drugs from the same class i.e. sulphonylureas, sulphonamides or to any ingredients of the glipizide table. Glipizide is not contraindicated in patient with sulfa allergy.

    Q. Can you take glipizide with or without metformin?

    You can take glipizide with or without metformin. However, always follow doctor's advice regarding its use.

    Q. Can I take glipizide with insulin?

    Glipizide, when used with insulin, can help to control high blood sugar levels. Taking them together can help to lower the dose of insulin but there could also be an increased risk of hypoglycemia. Dose of these medicines may need to be adjusted along with regular blood sugar level monitoring.

    Q. Can I take glipizide with levothyroxine?

    When levothyroxine is taken with glipizide, it may compromise the blood sugar controlling effect of glipizide. However, levothyroxine and glipizide can be taken together at a dose and schedule advised by your doctor.

    Q. Can I take glipizide with paracetamol (Tylenol)?

    Glipizide and paracetamol have no known adverse drug interactions and can be taken together. However, always follow doctor's advice regarding its use.

    Q. Can I take glipizide with ibuprofen?

    Concomitant administration of glipizide with ibuprofen may cause excessive lowering of the blood sugar level (hypoglycemia). Ibuprofen can be taken with glipizide if indicated provided that you follow the advice of the doctor regarding the dose and schedule of use of drugs.

    Q. Does Glipizide cause weight gain?

    Yes, Glipizide can cause weight gain. It is advisable to closely monitor your diet and do regular exercise while taking this medicine. Avoid skipping your meal as it can cause very low blood sugar levels and you may end up snacking or taking a lot of sugars.

    Q. Is Glipizide a Thiazolidinedione?

    No, Glipizide is not a Thiazolidinedione, it is a sulfonylurea. However, both are antidiabetic medicines but belong to a different group of medicines.

    Q. Is Glipizide useful in the management of gestational diabetes?

    Glipizide is not advised to be used for the management of gestational diabetes. Use of Insulin is advised during pregnancy to control the blood glucose levels.

    Q. Can I skip Glipizide for few days?

    No, Glipizide should not be skipped, as it can make your diabetes worse. If, you miss the dose by mistake, take it as soon as you remember.

    Content on this page was last updated on 17 May, 2019, by Dr. Varun Gupta (MD Pharmacology)