Gliclazide + Pioglitazone + Metformin

This is a combination of three antidiabetic medicines: Gliclazide, Pioglitazone and Metformin. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Pioglitazone is a thiazolidinedione which increases insulin sensitivity. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and further increasing the body's sensitivity to insulin.

Hypoglycemia (low blood sugar level), Nausea, Altered taste, Diarrhoea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection