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Glibenclamide + Metformin + Pioglitazone

Information about Glibenclamide + Metformin + Pioglitazone

How Glibenclamide + Metformin + Pioglitazone works

Glibenclamide + Metformin + Pioglitazone is a combination of three antidiabetic medicines: Glibenclamide , Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Common side effects of Glibenclamide + Metformin + Pioglitazone

Hypoglycemia (low blood glucose level), Nausea, Diarrhea, Headache, Weight gain, Anemia (low number of red blood cells), Vomiting, Flatulence
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MD (Pharmacology), MBBS
Last updated
18 Feb 2020 | 11:54 AM (UTC)

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Expert advice for Glibenclamide + Metformin + Pioglitazone

  • Take it with food to lower your chance of having an upset stomach.
  • It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).


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