Enfortumab Vedotin
Written By Dr. Sakshi Jain
Reviewed By Dr. Rajeev SharmaLast updated 09 Sep 2025 | 07:06 PM (UTC)
Enfortumab Vedotin Uses
Enfortumab Vedotin is used in the treatment of cancer.
How Enfortumab Vedotin works
Enfortumab Vedotin is an antibody–drug conjugate. The antibody part specifically attaches to a protein called Nectin-4 found on urothelial cancer cells. Once attached, it delivers a chemotherapy payload (monomethyl auristatin E) inside the cancer cell, where it disrupts cell division and causes cancer cell death.
Common side effects of Enfortumab Vedotin
Increased glucose level in blood, Increased liver enzymes, Altered blood counts, Increased creatinine level in blood, Rash, Fatigue, Peripheral neuropathy (tingling and numbness of feet and hand), Hair loss, Decreased appetite, Decreased sodium level in blood, Decreased phosphate level in blood, Diarrhea, Nausea, Itching, Increased uric acid level in blood, Dry eye, Taste change, Constipation, Weight loss, Abdominal pain, Dry skin
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Expert advice for Enfortumab Vedotin
- Always attend all scheduled infusion appointments; Enfortumab Vedotin works best when doses are not missed.
- Regular blood tests will be done to check your liver, kidneys, blood counts, and sugar levels.
- Use gentle skincare and moisturizers, since skin rash and dryness are common. Report any severe or spreading rash quickly.
- Drink enough fluids and eat light, balanced meals to reduce nausea, constipation, or diarrhea.
- Protect your eyes from dryness with lubricating drops if advised by your doctor.
- Avoid becoming pregnant or fathering a child during treatment. Use reliable birth control.
Frequently asked questions for Enfortumab Vedotin
Enfortumab Vedotin is given as an intravenous (IV) infusion into a vein at the hospital or clinic on specific days of a treatment cycle.
The treatment continues until your doctor sees enough benefit or until side effects make it unsafe to continue.
No. It is important to attend every infusion as scheduled. If you miss a dose, inform your doctor immediately to adjust your treatment plan.
Tell your doctor right away if you notice severe rash, numbness or tingling in your hands/feet, vision problems, extreme tiredness, or high blood sugar symptoms like increased thirst and urination.
Always inform your doctor about any prescription, herbal, or over-the-counter medicines, as some can interfere with your cancer treatment.
No. This medicine can harm the baby. Women should avoid pregnancy and breastfeeding during treatment and for some time after the last dose.