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    Information about Edaravone

    Edaravone uses

    Edaravone is used in the treatment of amyotrophic lateral sclerosis (ALS).

    How edaravone works

    Edaravone is an antioxidant. It has nootropic (enrichment of nerves) and neuroprotective properties. It works by slowing the nerve damage caused by harmful chemicals (free radicals). This delays the progression of amyotrophic lateral sclerosis (ALS) symptoms by reducing the oxidative stress (an imbalance between free radicals and antioxidants) in the brain.

    Common side effects of edaravone

    Headache, Bruise, Walking difficulties, Allergic reaction
    Content Details
    Written By
    Dr. Swati Mishra
    Reviewed By
    Dr. Khushbu Goel
    DM, MD
    Last updated on:
    18 Feb 2020 | 05:21 PM (IST)
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    Read Our Editorial Policy

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    Expert advice for Edaravone

    • Edaravone slows decline of physical function and helps relieve symptoms of amyotrophic lateral sclerosis (ALS) such as muscle cramps and fatigue.
    • It is given through a needle into a vein by your healthcare provider.
    • It takes about 60 minutes to receive a full dose of Edaravone.
    • Wear relaxed, loose-fitting clothing and keep yourself hydrated when treated with this medicine.
    • Inform your doctor if you are pregnant or breastfeeding.
    • Inform your doctor immediately  if you experience itching, swelling of the lips, tongue, or face, breathing problems or have trouble swallowing after receiving this medicine.
    • Inform your doctor if you have a known allergy to sulfa drugs.

    Frequently asked questions for Edaravone


    Q. What are the side effects of Edaravone?

    The most common side effects of Edaravone include confusion, headache, and difficulty in walking. Other uncommon side effects are skin allergy (rash and itching), breathing difficulty, chest tightness, wheezing, coughing (especially in people with asthma), and fungal infections.

    Q. Can amyotrophic lateral sclerosis (ALS) be cured by?

    Edaravone is used to treat amyotrophic lateral sclerosis (ALS). ALS is a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken. Edaravone works by slowing the nerve damage associated with the worsening of ALS symptoms.

    Q. Can ALS be prevented?

    There are no studies to support if ALS can be prevented or not. However, one can reduce the possibility of acquiring the disease by knowing various risk factors. The risk factors associated with ALS include smoking and exposure to pesticides and insecticides. In addition to that, another report suggests that people who have served in the military can also have high risks of developing ALS.

    Q. What should I tell my doctor before taking Edaravone?

    Inform your doctor or pharmacist if you are allergic to edaravone, any other medications, sodium bisulfite, or any of the ingredients in Edaravone injection. If you are taking or planning to take any other prescription and nonprescription medications, vitamins, and nutritional supplements inform your doctor beforehand. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor if you have or have ever had asthma or if you are pregnant or planning to conceive, or are breastfeeding. If you become pregnant while receiving edaravone, call your doctor.

    Q. Who is more likely to get affected by ALS? Is it age or gender specific?

    Caucasians and non-Hispanics are most likely to develop the disease. About 5 to 10 percent of all ALS cases are familial, which means that an individual inherits the disease from his or her parents. ALS can strike at any age, symptoms most commonly develop between the ages of 55 and 75. It is slightly more likely to develop in men than in women. However, as we age the difference between men and women disappears. Furthermore, some studies suggest that military veterans are about 1.5 to 2 times more likely to develop ALS because of toxin exposure during warfare.

    Q. Why so many veterans and athletes get ALS?

    Researchers have suggested that exposure to toxins during warfare, or strenuous physical activity, are possible reasons for why some veterans and athletes may be at increased risk of developing ALS.

    Q. What are the early symptoms of ALS?

    The early symptoms of ALS include muscle twitches in the arm, leg, shoulder, or tongue, muscle cramps, tight and stiff muscles (spasticity), muscle weakness affecting an arm, a leg, neck or diaphragm, slurred and nasal speech and difficulty in chewing or swallowing. For many individuals the first sign of ALS may appear in the hand or arm as they experience difficulty with simple tasks such as buttoning a shirt, writing, or turning a key in a lock. In other cases, symptoms initially affect one of the legs, and people experience awkwardness when walking or running or they notice that they are tripping or stumbling more often.

    Content on this page was last updated on 18 February, 2020, by Dr. Varun Gupta (MD Pharmacology)