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How it works

Drospirenone is progesterone, and together with estradiol, it can provide contraception by suppressing release of ovum (eggs) from your ovary, and interfering with other mechanisms that support occurrence of pregnancy. It suppresses the natural progesterone in the body, and thereby helps in PMDD and acne. Its mechanism of action in prevention of osteoporosis is not known.

Common side effects

Adrenal insufficiency, Rash, Vaginal discharge, Headache, Dizziness, Back pain, Increased appetite, Pain in extremity, Decreased libido, Abdominal distension, Cushing syndrome, Sleepiness, Vomiting, Nausea, Edema, Abdominal pain, Lower abdominal pain, Breast pain, Hair loss, Fatigue, Acne, Hot flushes, Thrombophlebitis, Diarrhoea, Irregular menstrual cycle, Cushingoid syndrome, Increased blood pressure, Depression, Mood changes, Nervousness, Constipation, Increased glucose level in blood, Breathing difficulty

Available Medicine

No medicine available

Expert advice

Do not take drospirenone, if you or your family has a history of breast cancer; liver disease or gall bladder disease; diabetes; depression; fits; serious inflammation of any part of gastrointestinal tract Crohn’s disease or ulcerative colitis.; hemolytic uremic syndrome (a disorder of blood clotting causing failure of the kidneys); sickle cell anemia (an inherited disease where the red blood cells are abnormal in shape); elevated levels of fat in the blood.
  • Do not take drospirenone, if you are about to undergo surgery, or have been bed-ridden or immobile for a long time; if you have just given birth.
  • Avoid taking drospirenone, if you have an pain and swelling over one or more veins under the skin;varicose veins; systemic lupus erythematosus (disease where the body’s cells are attacked by one’s own immune system, causing joint pain and swelling, fever, skin rash etc.); discoloration of the skin on the face or neck known as “pregnancy patches” (chloasma); hereditary swelling in lips and face (angioedema).
  • Drospirenone has to be taken with ethinyl estradiol starting from Day 2-5 of your menstrual cycle. However, dosage may vary depending on your condition. Please follow the instructions of your doctor, as its correct use is critical.
  • Avoid direct sunlight or ultraviolet light.
  • Do consult a doctor if there is appearance of blood clot in the body characterized by pain, swelling and warmth of affected leg (deep vein thrombosis) or breathlessness, irregular heart beat etc (thrombosis in lungs) .

Frequently asked questions


Q. Is drospirenone an antiandrogen/diuretic?
No, drospirenone belongs to a class of medication called as synthetic progesterone
Q. Is drospirenone same as Levonorgestrel?
Drospirenone and Levonorgestrel belong to same group of medication called synthetic progesterone, and are used in combination with ethinyl estradiol as oral contraceptives
Q. Does drospirenone help in acne/weight loss?
Drospirenone is used in the treatment of acne. No effect on weight has been reported
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Q. Does drospirenone cause weight gain, hair loss, melasma?
No, clinically observable hair loss, weight gain or melasma has been reported
Q. Does Loestrin (ethinyl estradiol and norethindrone) / Alesse (levonorgesteral and ethinyl estradiol) contain drospirenone?
No, these drugs do not contain drospirenone
Q. Why does drospirenone cause blood clot?
Drospirenone and estrogen increase the viscosity of blood by inhibiting the breakdown of certain factors that promote blood clotting.

Content on this page was last updated on 10 February, 2017, by Dr. Varun Gupta (MD Pharmacology)