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Desloratadine + Montelukast

Written By Dr. Sakshi JainReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:37 AM (UTC)

Desloratadine + Montelukast Uses

Desloratadine+Montelukast is used for sneezing and runny nose due to allergies.

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How Desloratadine + Montelukast works

Desloratadine + Montelukast is a combination of two medicines: Desloratadine and Montelukast, which treats sneezing and runny nose caused due to allergies. Desloratadine is an antiallergic which blocks the action a chemical messenger (histamine) responsible for runny nose, watery eyes and sneezing. Montelukast is a leukotriene antagonist. It works by blocking the action of another chemical messenger (leukotriene). This reduces inflammation (swelling) in the airways and nose, and improves symptoms.

Common side effects of Desloratadine + Montelukast

Diarrhea, Dryness in mouth, Fatigue, Headache, Muscle pain, Sleepiness, Pain during periods, Upper respiratory tract infection, Fever, Pharyngitis, Cough, Abdominal pain, Otitis media (infection of ear), Influenza
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Expert advice for Desloratadine + Montelukast

  • You have been prescribed Desloratadine + Montelukast to help relieve symptoms of allergy such as runny nose, sneezing, watery eyes, and cough.
  • Be cautious while driving or doing anything that requires concentration as Desloratadine + Montelukast can cause dizziness and sleepiness.
  • Do not drink alcohol while taking Desloratadine + Montelukast as it may cause increased sleepiness.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Stop taking Desloratadine + Montelukast at least three days before taking an allergy test as it can affect the test results.

Frequently asked questions for Desloratadine + Montelukast

No, Desloratadine+Montelukast should be continued as advised by the doctor. If you experience any problem due to Desloratadine+Montelukast, consult the doctor for re-evaluation.
Yes, the use of Desloratadine+Montelukast can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. You may use lip balm if your lips are also dry.
Do not take it with any fruit juices including apple, orange or grapefruit, as they might make the drug less effective. Avoid drinking alcohol while taking Desloratadine+Montelukast. Drinking alcohol will increase the severity of drowsiness or sleepiness caused by Desloratadine+Montelukast.
No, taking more of this medicine will not make it more effective, rather it can increase the risks of side effects. If the symptoms are getting severe, please consult the doctor for re-evaluation.
No, Desloratadine+Montelukast cannot be recommended to breastfeeding mothers. Inform your doctor if you are breastfeeding the baby.