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Dapagliflozin is used alone or in combination in adults for the treatment of type II diabetes.

How it works

Dapagliflozin belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by blocking the action of the SGLT2 receptors present in the kidneys thereby decreasing the reabsorption of glucose from urine to blood and increasing its excretion through urine resulting in lowering of the blood glucose level.

Common side effects

Frequent urge to urinate, Dizziness, Fall in blood sugar level, Urinary tract infection


Expert advice

  • You should start dapagliflozin treatment only if your diabetes is not controlled with diet and exercise related modifications, and medicines, and if you are intolerant to metformin.
  • Consult your doctor for a dose modification if you are elderly, or have kidney failure or liver failure. 
  • Dapagliflozin is not recommended for use in children (<18 years old).
  • Talk to your doctor before taking dapagliflozin if you are taking pioglitazone or drugs that promote removal of water from body (diuretics).
  • Exercise caution while on dapagliflozin treatment as strenuous exercise, fever, infection, surgery, trauma, dieting, and skipping meals can affect your blood sugar levels.
  • Taking dapagliflozin along with insulin, insulin analogues or sulphonylurea (glipizide, glibenclamide, gliclazide, glimepiride) my cause hypoglycemia (excessively low blood glucose level). If hypoglycemic, eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • Do not take if allergic to dapagliflozin or any of its ingredients.
  • Avoid if Patient is suffering from type 1 diabetes.
  • Do not take if suffering from diabetic ketoacidosis (increased ketone bodies in blood).
  • Avoid if Patient have fever, infection, injury, or illness with vomiting or diarrhea.
  • Avoid if Patient is suffering from adrenocortical or pituitary problems.

Frequently asked questions


Q. How long does dapagliflozin take to work?
Dapagliflozin works 2 hour after its administration wherein it reaches peak concentration.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)