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Chlorthalidone is used to treat high blood pressure (hypertension), heart failure, and to reduce the fluid retention that occurs with some kidney or liver diseases (edema), and to treat a condition in which an individual produces large amounts of dilute urine and is constantly thirsty (diabetes insipidus).

How it works

Chlorthalidone belongs to class of medications called thiazide diuretics. It acts by increasing excretion of sodium and potassium in the urine, which causes elimination of the excess water from body.

Common side effects

Cramps, Dizziness, Hair loss, Headache, Loss of appetite, Muscle weakness, Stomach pain, Vomiting, Diarrhoea, Excessive thirst


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Expert advice

  • Avoid drinking alcohol, which can increase some of the side effects of chlorthalidone.
  • Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink.
  • Do not take chlorthalidone and potassium salt or a potassium-sparing diuretic, if you are taking ACE inhibitors.

Frequently asked questions


Q. What is chlorthalidone/Hydrazine 12.5?
Chlorthalidone belongs to class of medications called thiazide diuretics.
Q. Is chlorthalidone/Hydrazine 12.5 a generic drug?
Yes, chlorthalidone is the generic name and hydrazine 12.5 is brand name.
Q. Is chlorthalidone an ace inhibitor/potassium sparing diuretic/sulfa drug/benzodiazepine/a blood thinner?
No, chlorthalidone belongs to class of medication called as thiazide diuretics.
Q. Is chlorthalidone a water pill?
Yes, it is a diuretic and also called as ‘water pill’.
Q. Is chlorthalidone better than hydrochlorothiazide?
Chlorthalidone and hydrochlorothiazide belongs to same category of drugs with similar action, but their effect may vary upon individual response.
Q. Can I take chlorthalidone/Hydrazine 12.5 with ibuprofen/Excedrin/Tylenol?
There is no observed drug interaction. Always consult your doctor regarding its use.
Q. Can amitriptyline cause weight loss: gain/cough/low potassium/high blood sugar/erectile dysfunction?
Amitriptyline can cause low potassium/high blood pressure. Patients should consult the doctor regarding the possible side effects.

Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)