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    Information about Chlorthalidone

    Chlorthalidone uses

    Chlorthalidone is used for Hypertension (high blood pressure). It treats oedema (fluid overload) associated with heart, liver, kidney or lung disease.

    How chlorthalidone works

    Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.

    Common side effects of chlorthalidone

    Headache, Nausea, Increased blood uric acid, Decreased potassium level in blood, Glucose intolerance, Altered blood lipid level
    Content Details
    Written By
    Dr. Betina Chandolia
    MDS, BDS
    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    18 Feb 2020 | 05:21 PM (IST)
    Want to know more?
    Read Our Editorial Policy

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    Expert advice for Chlorthalidone

    • Take it in the morning with breakfast to avoid getting up at night to urinate.
    • It makes you feel dizzy. Avoid driving and attention requiring activity until you know how it affects you.
    • Avoid alcohol intake while taking Chlorthalidone as it may increase the dizziness. 
    • It may cause a sudden drop of sodium level in blood. Avoid low sodium diet while you are taking this medication.
    • Monitor your blood pressure after starting Chlorthalidone, and notify your doctor if it does not lower down.
    • Notify your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
    • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. 

    Frequently asked questions for Chlorthalidone


    Q. Can I drink alcohol while taking Chlorthalidone?

    No, do not take alcohol while on treatment with Chlorthalidone. Taking alcohol with Chlorthalidone may lower your blood pressure suddenly making you feel dizzy and lightheaded.

    Q. What happens if I take more than the recommended dose of Chlorthalidone?

    If you take more than the prescribed dose of Chlorthalidone, you may experience nausea, lightheadedness, weakness, fast or irregular heart beat, sleepiness, muscle cramps and pain, difficulty in breathing. Taking this medicine in high doses may even cause a heart attack. In a situation like this, contact your doctor immediately or seek emergency help in a nearby hospital.

    Q. Can I take ibuprofen with Chlorthalidone?

    This combination is best avoided since the two medicines may interfere with each other. However, if your doctor advises you to take both ibuprofen and Chlorthalidone, you will need to keep a regular check on your blood pressure and also monitor your kidney function tests.

    Q. Does Chlorthalidone increase uric acid? Can it cause gout?

    Yes, Chlorthalidone may raise uric acid levels. However, the occurrence of gout due to Chlorthalidone is very rare.

    Q. Does Chlorthalidone cause skin cancer?

    No, there have been no reports of Chlorthalidone causing skin cancer. However, in rare cases, this medicine can make the skin more sensitive to sunlight than usual. If you are exposed to direct sunlight you may get skin rash, so wear protective clothing and use sunscreen.

    Content on this page was last updated on 18 February, 2020, by Dr. Varun Gupta (MD Pharmacology)