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Chlorthalidone is used in fluid retention (edema), heart failure, increased blood pressure and kidney stone.

How it works

Chlorthalidone lowers the blood pressure and swelling by removing extra water and electrolytes from the body.

Common side effects

Headache, Nausea, Increased blood uric acid, Decreased potassium level in blood, Glucose intolerance, Altered blood lipids

Available Medicine

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Expert advice

  • Avoid drinking alcohol, which can increase some of the side effects of chlorthalidone.
  • Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink.
  • Do not take chlorthalidone and potassium salt or a potassium-sparing diuretic, if you are taking ACE inhibitors.

Frequently asked questions



What is chlorthalidone/Hydrazine 12.5?
Chlorthalidone belongs to class of medications called thiazide diuretics


Is chlorthalidone/Hydrazine 12.5 a generic drug?
Yes, chlorthalidone is the generic name and hydrazine 12.5 is brand name


Is chlorthalidone an ace inhibitor/potassium sparing diuretic/sulfa drug/benzodiazepine/a blood thinner?
No, chlorthalidone belongs to class of medication called as thiazide diuretics

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Is chlorthalidone a water pill?
Yes, it is a diuretic and also called as ‘water pill'


Is chlorthalidone better than hydrochlorothiazide?
Chlorthalidone and hydrochlorothiazide belongs to same category of drugs with similar action, but their effect may vary upon individual response


Can I take chlorthalidone/Hydrazine 12.5 with ibuprofen/Excedrin/Tylenol?
There is no observed drug interaction. Always consult your doctor regarding its use


Can amitriptyline cause weight loss: gain/cough/low potassium/high blood sugar/erectile dysfunction?
Amitriptyline can cause low potassium/high blood pressure. Patients should consult the doctor regarding the possible side effects.

Content on this page was last updated on 13 April, 2017, by Dr. Varun Gupta (MD Pharmacology)