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Calcium Folinate

INFORMATION

Uses

Calcium Folinate is used in the treatment of ovarian cancer, blood cancer, hemorrhagic cystitis and methotrexate toxicity.

How it works

Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP and thrymidylate synthetase, enhances flourouracil activity and neutralises the effects of folic acid antagonists such as methotrexate but increases those of 5-fluorouracil.

Common side effects

Anaphylactic reaction, Fever, Hypersensitivity reaction, Urticaria

AVAILABLE MEDICINE


Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)