As an antidote to methotrexate, Folate deficiency anaemia, Megaloblastic anaemia, Nausea and vomiting, Suspected methotrexate overdosage, To counteract the folate-antagonist action of methotrexate.
How it works
Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP and thrymidylate synthetase, enhances flourouracil activity and neutralises the effects of folic acid antagonists such as methotrexate but increases those of 5-fluorouracil.
Common side effects
Anaphylactic reaction, Fever, Hypersensitivity reaction, Urticaria