Home>drugs by ailments>Neuropathic pain>amitriptyline + pregabalin

Amitriptyline + Pregabalin

Information about Amitriptyline + Pregabalin

Amitriptyline + Pregabalin Uses

Amitriptyline+Pregabalin is used in the treatment of neuropathic pain.

How Amitriptyline + Pregabalin works

Amitriptyline + Pregabalin is a combination of two medicines: Amitriptyline and Pregabalin. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves). Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells.

Common side effects of Amitriptyline + Pregabalin

Constipation, Weight gain, Sleepiness, Dizziness, Tiredness, Blurred vision, Dryness in mouth, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing), Difficulty in urination, Uncoordinated body movements
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Ashish Ranjan
MD (Pharmacology), MBBS
Last updated
03 Apr 2024 | 04:57 PM (UTC)

We provide you with authentic, trustworthy and revelant information

Want to know more

Available Medicine for Amitriptyline + Pregabalin

Maxgalip ATSun Pharmaceutical Industries Ltd
₹2791 variant(s)
NeugatripSun Pharmaceutical Industries Ltd
₹2591 variant(s)
Amnurite PHealth N U Therapeutics Pvt Ltd
₹2111 variant(s)
Neugalin AShasun Pharmaceuticals Ltd
₹1471 variant(s)
Gabrica ATSparsh Remedies Pvt Ltd
₹1891 variant(s)
GabritabSparsh Remedies Pvt Ltd
₹1391 variant(s)
Amicobal PGErgos Life Sciences
₹2071 variant(s)
Amnuring PCentaur Pharmaceuticals Pvt Ltd
₹2111 variant(s)
Amnurex PVayastha Naturals Private Limited
₹1501 variant(s)
Jesgab-TJes Pharmacia Private Limited
₹1771 variant(s)

Frequently asked questions for Amitriptyline + Pregabalin

Amitriptyline + Pregabalin

Q. What is Amitriptyline+Pregabalin?

Amitriptyline+Pregabalin is a combination of two medicines: Pregabalin and Amitriptyline. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on the patient's brain, thereby decreasing the pain sensation.

Q. Can I stop taking Amitriptyline+Pregabalin when my pain is relieved?

No, you should not stop taking Amitriptyline+Pregabalin even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Amitriptyline+Pregabalin, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.

Q. How to manage weight gain associated with the use of Amitriptyline+Pregabalin?

Amitriptyline+Pregabalin can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat foods that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits, and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will also help prevent weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight.

Q. Can the use of Amitriptyline+Pregabalin cause sleepiness or drowsiness?

Yes, Amitriptyline+Pregabalin may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while taking this medicine.

Q. Can the use of Amitriptyline+Pregabalin affect my sex life?

The use of Amitriptyline+Pregabalin can affect the sexual life of both men and women. Different sexual problems can occur due to Amitriptyline+Pregabalin like decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort during intercourse. If you experience these problems, discuss with your doctor but do not stop taking Amitriptyline+Pregabalin.

Q. Can the use of Amitriptyline+Pregabalin change the color of urine?

Yes, Amitriptyline+Pregabalin can change the color of the urine to blue or green. This change of color is expected while using Amitriptyline+Pregabalin, and it is not harmful. Your urine color becomes normal once you stop taking Amitriptyline+Pregabalin.

Q. Are there any serious side effects associated with the use of Amitriptyline+Pregabalin?

Serious side effects with Amitriptyline+Pregabalin are uncommon and rare. Tell your doctor as soon as possible if you notice changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior such as restlessness, nervousness, or excitement, signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and may need urgent medical attention.

Q. How long will Amitriptyline+Pregabalin take to act?

An initial benefit with Amitriptyline+Pregabalin may be seen after 2 weeks of treatment. However, it may take around 2-3 months to see full benefit. It may even take longer in some patients.

Q. What if I forget to take Amitriptyline+Pregabalin?

If you forget to take the scheduled dose of Amitriptyline+Pregabalin and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect due to overdosage. If you are not sure what to do, ask your doctor about taking Amitriptyline+Pregabalin.

Q. What if I take too much of this drug by mistake?

In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteady when walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heart beat.

Q. Will a higher than the recommended dose of Amitriptyline+Pregabalin be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

Q. Is there anything I need to avoid while taking Amitriptyline+Pregabalin?

Amitriptyline+Pregabalin may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while taking Amitriptyline+Pregabalin. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Amitriptyline+Pregabalin can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.

Q. How often should I see the doctor?

You may need to see your doctor regularly if you have started taking Amitriptyline+Pregabalin. However, you must consult your doctor if the recommended doses do not relieve your symptoms or you experience some unwanted side effects that affect your routine activities.

Q. What are the instructions for the storage and disposal of Amitriptyline+Pregabalin?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

INDIA’S LARGEST HEALTHCARE PLATFORM

260m+
Visitors
31m+
Orders Delivered
1800+
Cities
Get the link to download App

Connect

  • Social Links
  • Want daily dose of health?
Download App
Reliable

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

LegitScript approved
India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform

Know more about Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.

© 2024 Tata 1mg. All rights reserved. All medicines are dispensed in compliance with the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945. We do not process requests for Schedule X and habit forming drugs.