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Valproic Acid



Bipolar disorders, epilepsy, seizures, migraine, schizophrenia, status epilepticus.

How it works

Valproic Acid binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic Acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

Common side effects

Dizziness, Fatigue, Hair loss, Hepatitis (viral infection of liver), Liver toxicity, Indigestion, Nausea, Tremor, Weight gain


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Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)