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    Information about Tibolone

    Tibolone uses

    How tibolone works

    Tibolone is a hormonal medication. It has effects similar to estrogen, progesterone and androgen. It substitutes for the loss of estrogen production in postmenopausal women and treats menopausal symptoms such as hot flashes, night sweats and vaginal problems. It also prevents bone loss following menopause.

    Common side effects of tibolone

    Lower abdominal pain, Breast tenderness, Uterine bleeding , Abnormal hair growth, Vaginal discharge, Endometrial hyperplasia
    Content Details
    Written By
    Dr. Arpit Bhatnagar
    PGDHHM - Hospital and Healthcare Management, BDS
    Reviewed By
    Dr. Shilpa Garcha
    Writing in Medical Sciences, Medical Writing, Advanced PG Diploma in Clinical Research
    Last updated on:
    02 Jan 2019 | 04:40 PM (IST)
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    Expert advice for Tibolone

    • Tibolone is used as a part of hormone replacement therapy to relieve symptoms of menopause such as hot flushes, vaginal dryness, depression, and night sweats.
    • It may also be used for preventing osteoporosis in women who have attained menopause and are at high risk of fractures.
    • Take it at the same time everyday to help you remember to take it.
    • It may cause bleeding or spotting in between menstrual periods. Let your doctor know if this occurs frequently.
    • Stop taking Tibolone and inform your doctor immediately if you get severe headaches, stabbing pains or swelling in one leg, and pain on breathing. These could be symptoms of a blood clot in a vein.
    • Ensure that you regularly check your breasts for any changes and undergo regular breast screening and cervical smear tests while on treatment with this medicine.
    • Do not use Tibolone if you have a history of blood clots and liver disease. 

    Frequently asked questions for Tibolone


    Q. What is Tibolone used for?

    Tibolone works similar to the estrogen and progesterone hormones naturally produced by the body. It helps in treating estrogen deficiency symptoms like hot flush (red and warm face), vaginal dryness in women who have achieved menopause for more than one year. It is also used to prevent osteoporosis (thinning and weakening of bone) in post-menopausal women, who are at high risk of fractures and cannot take other preventive medicines for osteoporosis.

    Q. How and in what dose should I take Tibolone?

    The daily dose of Tibolone is once per day. However, the dose may vary as per your condition so, take Tibolone strictly as per the advice of your doctor. It can be taken with or without food preferably, at the same time of each day, to ensure consistent level of medicine in your body.

    Q. What if I miss to take Tibolone?

    If you miss a dose, you should take it as soon as possible. If the dose was missed by more than 12 hours, you should not take the missed dose and simply continue the usual dosing schedule. Missing a dose may increase the likelihood of breakthrough vaginal bleeding or spotting (blood stain).

    Q. What are the common side effects which I can experience while taking Tibolone?

    The common side effects caused by Tibolone are lower abdominal pain, abnormal hair growth, breast tenderness, endometrial hyperplasia (thickening of uterus lining) and vaginal discharge. Most of these symptoms are temporary. However, if they persist, check with your doctor as soon as possible.

    Q. Is Tibolone hormone replacement therapy (HRT)?

    Yes, Tibolone is a hormone replacement therapy that replaces estrogen in postmenopausal women, or women with estrogen deficiency due to ovarian failure or surgical ovarian removal

    Content on this page was last updated on 02 January, 2019, by Dr. Varun Gupta (MD Pharmacology)