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Tacalcitol is used for the treatment of plaque psoriasis (the most common form of the disease and appears as raised, red patches covered with a silvery white build-up of dead skin cells or scale).

How it works

Tacalcitol is derivative of vitamin D₃ belongs to a class of drugs called antipsoriatics. It binds to the keratinocyte (a type of skin cell) vitamin D receptor to the same extent as the natural vitamin D3. It acts by normalising cell growth and development in the skin. It prevents the excessive growth rate of skin cells that leads to scaling of the skin characteristic of Psoriasis.

Common side effects

Allergic reaction, Redness of skin, Burning sensation, Irritation, Skin rash, Itching, Tingling sensation


Expert advice

  • Avoid contact with eyes. In case of accidental contact, rinse thoroughly with water.
  • Tell your doctor if you have or have had problems with kidneys or have a particular type of psoriasis called generalized pustular psoriasis or taking high doses of vitamin D. 
  • If tacalcitol is to be used in conjunction with UV treatment then UV radiation should be given in the morning and tacalcitol should be applied at bedtime.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if patient is allergic to tacalcitol or any of its ingredients.
  • Do not take if patient with high level of calcium in the blood (hypercalcemia).

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)