Suxamethonium

Suxamethonium is a nicotinic acetylcholine receptor non-competitive agonist

Suxamethonium is used in anesthesia to induce muscle relaxation during operations, to facilitate endotracheal intubation (help insert a tube into the windpipe), reduce strong muscle contraction

Suxamethonium apnoea occurs when a patient does not have the enzymes to metabolise the drug. Due to this, a patient may remain paralysed for an increased length of time and cannot breathe adequately at the end of an anaesthetic

The initial metabolite of Suxamethonium produces a transient negative chronotropic effect through its stimulation of sinus node muscarinic receptors. Repeated dosing or infusions of Suxamethonium may lead to bradycardia that is appropriately treated with atropine

Administration of suxamethonium may lead to depolarization and a large efflux of intracellular potassium into the plasma thereby resulting in hyperkalemia

Suxamethonium cause fasciculation by an action on some distal part of motor nerve fibres

Suxamethonium is still used during general anesthesia

Suxamethonium is a short-acting muscle relaxant which exerts a depolarizing effect at the neuromuscular junction. This effect is not reversible pharmacologically

Yes, Suxamethonium should not be used in burned patients

Suxamethonium sensitivity is when the drug remains active for a longer period of time than is usual due to which muscles stay relaxed

In normal therapeutic doses, Suxamethonium does not cross the placental barrier in sufficient amounts.